An interventional study of Water in Low Water Intake and High Vasopressin, sponsored by Region Skane. Completed at 1 site in Sweden. Open to participants aged 20 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-07-03.
Sponsored by Region Skane · Not applicable, Interventional, and Prevention
This study evaluates increased hydration (1.5 L of water daily during 6 weeks) on top of habitual water intake in the lowering of the vasopressin marker copeptin and in the lowering of plasma glucose concentration in adults with signs of low water intake at recruitment (elevated levels of copeptin, high urine osmolality, low urine volume).
High plasma concentration of vasopressin (i.e. antidiuretic hormone) is a novel and independent risk factor for type 2 diabetes, the metabolic syndrome, cardiovascular disease and premature death. The main physiological role of vasopressin is to maintain constant plasma osmolality. Previous studies in rats and a Mendelian randomization study in humans suggest causality between elevated vasopressin concentration and elevated plasma glucose concentration. As vasopressin can be suppressed by increasing water intake, the investigators hypothesize that water supplementation in individuals with high vasopressin can lower plasma glucose and prevent diabetes.
The aim of this pilot study is to test if six weeks of water supplementation of 1.5 Liters of extra water per day in low-drinkers with high copeptin can significantly alter hydration markers in general and reduce plasma copeptin in particular. Furthermore, the investigators also aim at investigating whether this 6-week water intervention can significantly reduce fasting plasma glucose concentration.
Region Skane is the lead sponsor of 372 studies on the registry; 113 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
The participants increase their habitual daily water intake with 1.5 Liters of tap water per day during 6 weeks.
Dietary Supplement: Water
Increased daily water intake with 1.5 Liters of water per day on top of habitual water intake.
Fasting plasma copeptin concentration (pmol/L)
Change of fasting plasma copeptin between baseline and after 6 weeks of increased water intake.
Time frame: 6 weeks
24 hour urine osmolality (mosm/kg H2O)
Change of 24 hour urine osmolality between baseline and after 6 weeks of increased water intake.
Time frame: 6 weeks
24 hour urine volume (L/24h)
Change of 24 hour urine volume between baseline and after 6 weeks of increased water intake.
Time frame: 6 weeks
Drinking water (L/day)
Change of intake of tap and bottled water between baseline and after 6 weeks of increased water intake.
Time frame: 6 weeks
Total water (L/day)
Change of total water intake between baseline and after 6 weeks of increased water intake.
Time frame: 6 weeks
Fasting plasma glucose concentration (mmol/L)
Change of Fasting plasma glucose concentration between baseline and after 6 weeks of increased water intake.
Time frame: 6 weeks
Documents are hosted by the registry — open the source record to download them.
Plan to share: No
This study is completed, as verified in Jun 2018. You cannot join it, but the record below documents what was studied.
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Region Skane