An observational study in Mechanical Ventilation, sponsored by Yonsei University. Status unknown at 1 site in Korea, Republic of. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-02-12.
Sponsored by Yonsei University · Observational
The investigators aimed to develop integrated ultrasound guided mechanical weaning protocol in critically ill patients. The analysis will be taken (1) just before the spontaneous breathing trial in enrolled patients with mechanical ventilation and (2) in patients with tracheostomy who fail ventilator off.
Prolonged mechanical ventilation is associated with higher ventilator-associated pneumonia and ventilator-associated lung injury, longer intensive care unit and hospital days, increased mortality, and higher medical costs. However, some patients are difficult to wean from invasive mechanical ventilation. Typically, the difficulty in transitioning patients to spontaneous breathing may be categorized as simple transition, difficult transition, and prolonged transition.
There are a lot of predictors for weaning failure such as cardiac dysfunction, increased respiratory rate, diaphragm dysfunction, rapid shallow breathing index and so on. However, weaning failure involves complicated mechanisms that are not solved by one cause. Recently, P. Mayo published a review paper on ultrasonography evaluation during the weaning process. The investigators need to pay attention to this paper. While lots of previous predictors cannot explain the reason, ultrasound evaluation is a process of finding the cause as well as prediction for weaning failure. However, The investigators need a more practical and standardized ultrasound protocols for how to wean invasive mechanical ventilation. "Ultrasonographic mechanical weaning protocol" should not comprise just one indicator, but include various indicators such as upper airway stenosis, heart function, the status of the lung and pleura, diaphragmatic function, Etc. This integrated ultrasound protocol will help in successful weaning of invasive mechanical ventilation.
Yonsei University is the lead sponsor of 1,387 studies on the registry; 232 are open to participants now.
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Mechanically ventilation participants in a mixed intensive care unit
Exclusion Criteria:
Investigation of ultrasound indices associated with the success or failure of mechanical ventilation weaning
* Weaning success: stable without mechanical ventilator support during more than 48 hours * Weaning failure: unstable without mechanical ventilator support within 48 hours A) Type I respiratory failure: high flow oxygen support B) Type II respiratory failure: non-invasive ventilatory support C) Reintubation
Time frame: within 48 hours
A) In-ICU mortality
Time frame: 90 days after Ultrasonography
B) In-hospital mortality
Time frame: 90 days after Ultrasonography
C) Ventilator free day
Time frame: 90 days after Ultrasonography
D) ICU free day
Time frame: 90 days after Ultrasonography
Plan to share: Undecided
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This study is status unknown, as verified in Feb 2019. You cannot join it, but the record below documents what was studied.
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Yonsei University