An interventional study of Best Practice and Laboratory Biomarker Analysis in Malignant Neoplasm, sponsored by University of Southern California. Suspended at 1 site in United States. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-05-13.
Sponsored by University of Southern California · Not applicable, Interventional, and Supportive care
This trial studies how well virtual reality (VR) works in reducing pain and anxiety in cancer participants undergoing bone marrow biopsy or lumbar puncture. Virtual reality may impact pain and anxiety during and after the procedure.
PRIMARY OBJECTIVES:
I. To determine the feasibility of VR in patients undergoing procedural intervention.
SECONDARY OBJECTIVES:
I. To estimate differences between the two arms in terms of pain and anxiety. II. To document any adverse events that could possibly be attributed to the VR intervention.
EXPLORATORY OBJECTIVES:
I. Explore the use of biomarkers as a tool to reflect the impact of intervention.
OUTLINE: Participants are randomized to 1 of 2 arms.
ARM I: Participants undergo VR intervention peri-procedure (bone marrow biopsy or lumbar puncture) lasting until completion of the procedure.
ARM II: Participants receive standard of care during procedure (bone marrow biopsy or lumbar puncture).
9,365 studies on the registry are indexed under Neoplasms; 2,489 are open to participants now.
This study's planned enrollment of 60 is above the median of 50 across 7,253 interventional studies indexed under Neoplasms.
Browse Neoplasms studies →University of Southern California is the lead sponsor of 773 studies on the registry; 135 are open to participants now.
Of its 68 completed or terminated interventional studies of FDA-regulated products, 32 (47%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants receive the VR intervention during bone marrow biopsy or lumbar puncture lasting until completion of the procedure. Participants will be trained to use VR equipment prior to the bone marrow biopsy or lumbar puncture. The headset will cover both eyes with a strap along the back to hold the headset in place. The headset will be attached by a wire to a laptop which will power the headset and provide content. A remote control will be available for assistance in setting up or stopping the content in the case of an event. The VR content will consist of meditation and relaxing techniques through visual and auditory input which can last up to one hour. There will be minimal stimulatory effort to decrease excess movement for the procedure.
Other: Laboratory Biomarker Analysis · Device: Oculus Rift Headset · Other: Questionnaire Administration
Participants receive standard of care during bone marrow biopsy or lumbar puncture.
Other: Best Practice · Other: Laboratory Biomarker Analysis · Other: Questionnaire Administration
Receive standard of care
Also known as: standard of care, standard therapy
Correlative studies
Subject wears headset for virtual reality intervention during bone marrow biopsy or lumbar puncture procedure
Ancillary studies
Pain as assessed according to a visual analog scale (VAS)
A visual analogue pain scale is a validated pain measure. A 10 centimeter horizontal line with a 0 (no pain) on the far left and 10 (worst possible pain) on the far right. Participants rate pain intensity by drawing a mark on the line. Pain intensity is obtained by measuring from the 0 to the participant's mark on the line, yielding a score from 0 to 10.
Time frame: Up to 1 year
Anxiety
Will be assessed by the State-Trait Anxiety Inventory.
Time frame: Up to 1 year
This study is suspended, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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University of Southern California