An observational study in Papillomavirus Infections, sponsored by Peking Union Medical College Hospital. Status unknown at 1 site in China. Open to female participants aged 25 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-02-06.
Sponsored by Peking Union Medical College Hospital · Observational
Since other genital infections enhance HIV susceptibility by inducing inflammation, the investigators study the relationship between the vaginal microbiota composition and the risk of HPV infection, cervical cytological abnormalities.
Persistent infection with oncogenic Human Papillomavirus (HPV) is necessary but not sufficient for the development of cervical cancer. Additional factors correlated with HPV persistence include immunodeficiency caused by HIV, smoking, use of oral contraceptives and, more recently reported, vaginal dysbiosis. In a state of dysbiosis, there is a marked reduction of Lactobacillus and a high diversity of bacteria, with increased abundance of anaerobic bacterial species. Based on this, the investigators are going to analyze the changes of microbiota in women with high-risk HPV and the cervical lesions. And the investigators hope to figure out the difference and change in microbiota to realize the tanning of cervical lesions.
6,687 studies on the registry are indexed under Infections; 807 are open to participants now.
This study's planned enrollment of 151 is below the median of 240 across 2,136 observational studies indexed under Infections.
Browse Infections studies →Peking Union Medical College Hospital is the lead sponsor of 1,115 studies on the registry; 463 are open to participants now.
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Group A: HPV positive, and the participants who have not taken drugs and physical therapy in the past six months, nor have chronic diseases (such as DM), take their vaginal microorganisms (do not mention the past History issues). Group B: HPV negative in the past 12 months, taking the vaginal microorganisms.
Clinical diagnosis of HR-HPV results.
Exclusion Criteria:
Clinical diagnosis of vaginitis, immune disease, malignancy History of cervical lesions Pregnancy Clinical diagnosis of other serious systemic primary diseases, such as severe liver and kidney dysfunction Severe mental illness
Biological: Human Papillomavirus
women with high-risk Human Papillomavirus or not
Vaginal microbiota and HR-HPV infection
The persistence vaginal organism in HPV infection participants
Time frame: 12 months
Vaginal microbiota and the cervical lesion
The cervical cytology, HPV and the vaginal microbiota were evaluated
Time frame: 12 to 36 months
This study is status unknown, as verified in Feb 2019. You cannot join it, but the record below documents what was studied.
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Peking Union Medical College Hospital