An observational study in Red Blood Cell Disorder, sponsored by Imagine Institute. Recruiting at 25 sites in 3 countries. Per ClinicalTrials.gov, last updated 2026-09-09.
Sponsored by Imagine Institute · Observational
GR-Ex is a program labelled by Labex (Laboratory of Excellence) by the French Ministry of Higher Education and Research. This program aims to develop the means to improve knowledge in the physiology and pathologies of erythropoiesis, red blood cells and iron metabolism, and to develop new therapeutic protocols capable of providing added value in terms of innovation.
Imagine Institute is the lead sponsor of 31 studies on the registry; 15 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion of patients affected by red blood cell disorder and their non affected relatives
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Biological samples of blood for all patients. Biological samples of saliva, surgical remainder (skin, tumor, kidney,....), saliva, urine, hair.
Other: Biological sampling
Biological samples of blood for all relatives.
Other: Biological sampling
Biological samples including blood, surgical remainder, urine,...
Innovative markers of spleen fonctionality
Retention rate (%) of red blood cells using Microsphiltration compared with non affected subjects
Time frame: 20 years
Quantification of inflammation in sickle cell disease
Activation rate of circulating mastocytes (%)
Time frame: 20 years
Markers of post-artesunate hemolysis
Concentration of pitted red blood cells at day 3
Time frame: 20 years
Correlation between transfusion yield and the storage of red blood cell bags
Increasing in haemoglobin concentration at 6 hours post transfusion
Time frame: 20 years
Efficiency of Phosphodiesterase inhibitor on neutrophil adhesion in Sickle cell disease
Proportional change in adhesion rate (%) of neutrophils measured in the peripheral blood before and after treatment with phosphodiesterase inhibitors
Time frame: 20 years
Quantification of mitochondria removal during erythropoiesis in SDC patients, consequences on the mature RBC
Mitochondria rate and level of ROS in RBC measured by Flow Cytometry
Time frame: 20 years
Study of iron metabolism in Diamond-Blackfan Anemia patients
Dosage of iron metabolism parameters
Time frame: 20 years
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