An interventional study of Care with C-reactive protein assay in micro method in Respiratory Infection and Respiratory Infections in Children, sponsored by Centre Hospitalier Intercommunal Creteil. Completed at 14 sites in France. Open to participants aged 3 Years and older. Per ClinicalTrials.gov, last updated 2023-08-07.
Sponsored by Centre Hospitalier Intercommunal Creteil · Not applicable, Interventional, and Diagnostic
Respiratory infections, including episodes of coughing with fever, are the main cause of outpatient antibiotic prescription, while a minority of them are linked to bacterial infections requiring antibiotic. These prescriptions are often performed by general practitioners. These unnecessary antibiotic contribute to increased bacterial resistance, side effects and unnecessary costs. Campaigns for the correct prescription of antibiotics have had a real but partial or transient success.
C-reactive protein micro-method (POCT-CRP) could help to differentiate between viral and bacterial infections and thus contribute to the proper use of antibiotics. The decrease in prescription of antibiotics is likely to have an even stronger positive impact in countries like France, where prescription is high.
The objective of this study is to evaluate the use of POCT-CRP in the general practitioner's office in case of suspected respiratory infection.
6,687 studies on the registry are indexed under Infections; 807 are open to participants now.
This study's enrollment of 406 is above the median of 120 across 4,201 interventional studies indexed under Infections.
Browse Infections studies →Centre Hospitalier Intercommunal Creteil is the lead sponsor of 131 studies on the registry; 36 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
During a visit to the general practitioner for a clinical suspicion of respiratory infection, the doctor will practice a C-reactive protein assay in micro method. He will prescribe antibiotics according to the result of the dosage
Diagnostic Test: Care with C-reactive protein assay in micro method
Simple management of a patient coming for a suspicion of respiratory infection without dosage of the C-reactive protein in micro method
Care with C-reactive protein assay in micro method
Frequency of antibiotic therapy prescribed
with and without POCT-CRP
Time frame: 10 days
Frequency of antibiotic therapy prescribed in patients aged from 3 to 17 years old
with and without POCT-CRP
Time frame: 10 days
Frequency of antibiotic therapy prescribed in patients aged from 18 to 64 years old
with and without POCT-CRP
Time frame: 10 days
Frequency of antibiotic therapy prescribed in patients older than 65 years old
with and without POCT-CRP
Time frame: 10 days
Type of antibiotic prescribed
Time frame: 10 days
Frequency of complementary exam
with and without POCT-CRP
Time frame: 10 days
type of complementary exam
with and without POCT-CRP
Time frame: 10 days
Proportion of number of patients referred to emergency
with and without POCT-CRP
Time frame: 10 days
Proportion of number of patients with delayed antibiotic therapy
with and without POCT-CRP
Time frame: 10 days
number of prescription following the recommended algorythms
Adequacy between the proposed decision algorithm according to the C-reactive protein assay and the antibiotic prescription
Time frame: 10 days
Concordance between the prescription proposed by the decision algorithm as a function of the micro-CRP and the prescription realized: kappa coefficient
The assessment of the utility of the POCT procedure
Time frame: 10 days
COVID-19 positive patients
Number of COVID-19 positive patients by diagnostic method (From October 2020)
Time frame: 1 day
Plan to share: No
This study is completed, as verified in Aug 2023. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Intercommunal Creteil