An interventional study of HIIT group in Metabolic Disturbance, sponsored by Universidad Santo Tomas. Withdrawn at 1 site in Colombia. Open to male participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-03-25.
Sponsored by Universidad Santo Tomas · Not applicable, Interventional, and Prevention
This project offers the opportunity to obtain detailed measurements on the health of body composition, metabolic health, and intestinal microbial diversity in overweight adults; moreover to provide information about the effects of physical exercise on them. The aim of the research is to advance in the understanding of the mechanisms induced by physical exercise, which includes the measurement of nutritional parameters, clinical and biochemical biomarkers of hepatic/cardiometabolic health, as well as the application of differential proteomics technologies by means of Arrays of cytokines and intestinal microbiome, making this study a novel and pioneer in sensitive areas of primary health care in Latin America.
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Exclusion Criteria:
The HIIT modality consisted of 30-40 minutes (min) of steady-state, high-intensity training 3 d/wk on a stationary bicycle at the target heart rate (HR) range equivalent to 85% to 95% of the individual's maximum oxygen consumption rate (VO2max). Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 6-weeks.
Behavioral: HIIT group
The SIT modality consisted of 6 to 10 repetitions of a 30 s segment of all-out exercise interspersed with 2 min of recovery, 3 d/wk on a stationary bicycle at the target heart rate (HR) range equivalent to 90% to 95% of the individual's maximum oxygen consumption rate (VO2max).
Behavioral: HIIT group
Physical Training
Also known as: High/low volume exercise
Gut microbiota
Change from Baseline in the gut microbiota composition measured by amplicon sequencing
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Plasma metabolomic profile
Change from Baseline in the metabolomic profile will be also evaluated by a HPLC-MS approach
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Plasma hepatokines
Change from Baseline in the Chemerin will be measured using ELISA kits
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Plasma hepatokines
Change from Baseline in the Selenoprotein P will be measured using ELISA kits
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Plasma hepatokines
Change from Baseline in the Fetuin-A will be measured using ELISA kits
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Plasma hepatokines
Change from Baseline in the FGF21 (fibroblast growth factor 21) Leukocyte cell-derived will be measured using ELISA kits
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Glucose
Change from Baseline will be also evaluated by a spectroscopy
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Insulin
Change from Baseline will be also evaluated by a ELISA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Glycated hemoglobin
Change from Baseline will be also evaluated by a ELISA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Bioinflammatory blood markers
Change from Baseline measure of plasma IL-1 concentrations measured ELISA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Bioinflammatory blood markers
Change from Baseline measure of plasma IL6 concentrations measured ELISA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Bioinflammatory blood markers
Change from Baseline measure of plasma TNF-alfa concentrations measured ELISA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Bioinflammatory blood markers
Change from Baseline measure of plasma CRP concentrations measured ELISA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Body composition
Differences in body weight (kilograms) measured by DXA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Body composition
Differences in body fat (%) measured by DXA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Body composition
Differences in mass muscle measured by DXA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Physical fitness
Differences in Muscular strength (handgrip test) in kg
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Physical fitness
Differences in Maximum Oxygen Consumption (VO2 max K5 Gas Analyser) in ml/kg/min
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Energy substrate oxidation
Fat and carbohydrate oxidation in the fasted and postprandial state measured before and after the interventions using indirect calorimetry (K5 cosmed)
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Resting Metabolic Rate
Resting metabolic rate was measured before and after the interventions (K5 Cosmed)
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Plan to share: No
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This study is withdrawn, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.
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Universidad Santo Tomas