An interventional study of Frequent sit-to-stands and Stand More in Sedentary Lifestyle, sponsored by University of California, San Diego. Active, not recruiting at 1 site in United States. Open to female participants aged 55 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-06-14.
Sponsored by University of California, San Diego · Not applicable, Interventional, and Prevention
This protocol "Sedentary Behavior Interrupted: A randomized crossover trial of acute effects on biomarkers of healthy aging in the laboratory (Project 1)" is part of a National Institutes of Aging Program Grant called "Sedentary Time \& Aging Mortality and Physical Function (STAR). The overall purpose of the STAR program to is to better understand how to interrupt sitting time and the consequences for healthy aging in postmenopausal women. This protocol (also referred to Project 1 of the STAR program) is a 3-condition randomized crossover clinical trial of up to 86 postmenopausal women to test whether different interruptions to prolonged sitting improve metabolism.
The specific aims of this protocol include:
Aim 1. To investigate the acute effect of sitting interruption modalities on postprandial glucose and insulin concentrations, compared to prolonged sitting.
Aim 2. To investigate the acute effect of sitting interruption modalities on the physiologic parameters of endothelial function, compared to prolong sitting.
Aim 3. To explore the moderating effect of age.
University of California, San Diego is the lead sponsor of 958 studies on the registry; 191 are open to participants now.
Of its 110 completed or terminated interventional studies of FDA-regulated products, 70 (64%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Following a one-hour sitting run-in period, participants will sit for a 5-hour period including a mid-point bathroom break.
Following a 1-hour sitting run-in period, participants will sit for a 5-hour period including a 2-min stand every 15 min throughout the 5-hr protocol period and a mid-point bathroom break.
Behavioral: Frequent sit-to-stands
Following a 1-hour sitting run-in period, participants will sit for a 5-hour period including 5 8-minute standing breaks, 1 per hour, and a mid-point bathroom break.
Behavioral: Stand More
Participants will visit the clinic for a 6-hour monitoring period. Following a 1-hour sitting run-in period, participants will sit for an additional 5-hour period including a 2-min stand every 15 min throughout the 5-hr protocol period. Baseline, mid-point, and end-of-visit bathroom breaks for urine sample collection will be conducted, with additional bathroom breaks allowed as needed.
Also known as: Protocol B
Participants will visit the clinic for a 6-hour monitoring period. Following a 1-hour sitting run-in period, participants will sit for an additional 5-hour period including 5 8-minute standing interruptions, 1 per hour. Baseline, mid-point, and end-of-visit bathroom breaks for urine sample collection will be conducted, with additional bathroom breaks allowed as needed.
Also known as: Protocol C
Postprandial glucose
To investigate the acute effect of sitting interruption modalities on postprandial glucose compared to prolonged sitting.
Time frame: 5 hours
Insulin
To investigate the acute effect of sitting interruption modalities on insulin concentrations compared to prolonged sitting.
Time frame: 5 hours
Flow mediated dilation
To investigate the acute effect of sitting interruption modalities on flow mediated dilation compared to prolonged sitting
Time frame: 5 hours
Blood pressure
To investigate the acute effect of sitting interruption modalities on blood pressure compared to prolonged sitting.
Time frame: 5 hours
Documents are hosted by the registry — open the source record to download them.
Plan to share: Yes
This study is active, not recruiting, as verified in Jun 2024. You cannot join it, but the record below documents what was studied.
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University of California, San Diego