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CompletedNCT03486015Updated Apr 3, 2018

Oral Sweet Solution to Prevent Pain During Neonatal Hip Examination

An interventional study of Sterile water and 30% glucose in Pain, sponsored by Region Örebro County. Completed. Open to participants aged 37 Weeks and older. Per ClinicalTrials.gov, last updated 2018-04-03.

Sponsored by Region Örebro County · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
100
Allocation
Randomized
Ages
37 Weeks and older
Sex
All
01

Study summary

This study evaluates the pain relieving effect of oral glucose during hip examinations on healthy, fullterm infants.

Read the detailed description

All healthy, fullterm infants undergoes a medical examination after birth where 21 different components are assessed. One of the components is the hip examination which appears to be painful. Since painful experiences early in life can cause longterm negative effects it is important to treat pain during painful procedures.

One hundred healthy, fullterm infants were randomized to either glucose or sterile water orally before the routine medical examination before discharge from the maternity ward.

02

Conditions studied

  • Pain
03

Who can participate

Ages eligible
37 Weeks and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Healthy, fullterm infants that were undergoing a routine medical examination

Exclusion criteria

Exclusion Criteria:

  • Prematurity
  • Parents inability to speak Swedish well enough to give consent
  • Congenital malformations or other illnesses
  • Any pain-relieving medicine administered in the previous 24 hours
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment
100 participants (actual)

Study arms

  • Experimental
    30% glucose

    This group will be given 2 ml of 30% glucose in the mouth before the physical examination of the infant.

    Drug: 30% glucose

  • Placebo comparator
    Sterile water

    This group will be given 2 ml of sterile water in the mouth before the physical examination of the infant.

    Drug: Sterile water

Interventions

  • DrugSterile water

    2 ml of sterile water

  • Drug30% glucose

    2 ml of 30% glucose

05

What researchers measure

Primary outcomes

  1. Pain will be measured with ALPS-Neo (Astrid Lindgren and Lund children's hospitals pain and stress assessment scale for preterm and sick newborn infants, range 0-10 where higher number means a higher intensity of rated pain) by a nurse

    Pain assessment instrument

    Time frame: The assessment is made by the nurse when the physician starts with the hip examination, approximately 60 seconds after the study solution has been given.

  2. Pain will be measured by VAS (Visual analogue scale, range 0-10 where higher number means a higher intensity of rated pain) assessed by physician

    Pain assessment instrument

    Time frame: The physician will make the VAS assessment directly after the physical examination is done, approximately 10 minutes after the study solution has been given.

  3. Pain will be measured by VAS (Visual analogue scale, range 0-10 where higher number means a higher intensity of rated pain) assessed by parent

    Pain assessment instrument

    Time frame: The parents will make the VAS assessment directly after the physical examination is done, approximately 10 minutes after the study solution has been given.

  4. Total crying time will be measured

    Total amount of time (in minutes) the infant is crying during the examination.

    Time frame: The total crying time is measured throughout the examination from zero minutes until approximately 10 minutes after the study solution has been given with the help of a stopwatch.

  5. Crying time during hip examination

    The amount of time (in minutes) the infant is crying during the hip examination.

    Time frame: The total crying time is measured from approximately 3 minutes from the study solution has been given until the hip examination has been completed (approx. during 30 sec up to 1 min) with the help of a stopwatch

06

Study locations

No study locations are listed for this record.

07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03486015
Lead sponsor
Region Örebro County
Responsible party
Sponsor
First posted
Apr 3, 2018
Start date
Mar 1, 2016
Primary completion
Apr 10, 2017
Completion
Apr 10, 2017
Last update
Apr 3, 2018

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.

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