An interventional study of Anodal tDCS and Sham tDCS in Impulsive Behavior, sponsored by Najat Khalifa. Completed at 1 site in United Kingdom. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-02-25.
Sponsored by Najat Khalifa · Not applicable, Interventional, and Treatment
This study aims to use concurrent Transcranial Direct Current Stimulation (tDCS) and Magnetoencephalography (MEG) with measures of impulsivity to examine the neurobiological underpinnings of rapid response impulsivity (RRI) and how these can be modified using tDCS in healthy subjects.
Concurrent tDCS-MEG parallel arms single-blinded experimental design (right anodal v sham tDCS) will be employed in this study. The study will be conducted at the University of Nottingham, using a sample of student volunteers. This study aims to examine the influence of anodal tDCS on beta-band and alpha-band oscillatory activities, using an anti-saccade task administered before, during and after tDCS stimulation. It can potentially help understand the neurobiological mechanisms underpinning rapid response impulsivity and how these can be influenced by tDCS.
The research hypotheses are that (i) a generalised mechanism for top-down inhibitory control will play a vital role, whereby prefrontal beta-band activity initiates alpha-band activity for functional inhibition over the frontal eye fields and other areas in the neurocircuitry involved in RRI; (ii) anodal tDCS (as opposed to sham) delivered over the right DLPFC will enhance this mechanism; and (iii) there will be no significant correlations between measures of self-report impulsivity and performance on the anti-saccade task and measures of oscillatory activity.
158 studies on the registry are indexed under Impulsive Behavior; 31 are open to participants now.
This study's enrollment of 36 is below the median of 50 across 128 interventional studies indexed under Impulsive Behavior.
Browse Impulsive Behavior studies →This is the only study on the registry with Najat Khalifa as lead sponsor.
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Exclusion Criteria:
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The anodal tDCS electrode will be placed over the area corresponding to the right DLPFC (F4 of the EEG10-20 international system). The anodal tDCS condition will use a constant current of 2mA, delivered via gradual increase and decrease over 10 seconds at the onset and offset of stimulation (current ramps), respectively.
Device: Anodal tDCS
The sham (cathodal) electrode will be placed over the left supraorbital ridge. The current will be delivered only in the first 10 seconds, after which the stimulation will cease but with the electrodes still in place throughout the session.
Device: Sham tDCS
The experimental condition will use a constant current of 2mA for 20 minutes, delivered via gradual increase and decrease over 10 seconds at the onset and offset of stimulation (current ramps), respectively.
The anodal electrode will be placed over the supreorbital ridge. The current will be delivered only in the first 10 seconds, after which the stimulation will cease but with the electrodes still in place throughout the session. The session will last for 20 minutes.
Total number of correct anti-saccade (AS) trials
A measure of rapid response impulsivity (inhibitory control)
Time frame: Change from baseline after 20 minutes of tDCS
Total number of correct pro-saccade (PS) trials
A behavioral measure of rapid response impulsivity (inhibitory control)
Time frame: Change from baseline after 20 minutes of tDCS
Saccade latency for anti-saccade (AS) trials
A behavioral measure of rapid response impulsivity (inhibitory control)
Time frame: Change from baseline after 20 minutes of tDCS
Saccade latency for pro-saccade (PS) trials
A behavioral measure of rapid response impulsivity (inhibitory control)
Time frame: Change from baseline after 20 minutes of tDCS
Total Scores on the UPPS+P Impulsive Behaviour Scale
A self-report measure of impulsivity
Time frame: Baseline
Alpha and Beta band activity
A Cortical measure of inhibitory control recorded using Magnetoencephalography (MEG). MEG is a brain imaging technique.
Time frame: Change from baseline after 20 minutes of tDCS
Alpha and Beta band activity
Evaluation of mechanism of action of tDCS using MEG data
Time frame: During 20 minutes of tDCS stimulation
Plan to share: Undecided
Ran from Sep 2018 to primary completion in Feb 2019, 4 months.
Of 55 non-industry interventional studies with no phase under Impulsive Behavior, half reached primary completion within 26 months of starting (the median), counting those still running; a quarter within 13 and three quarters within 34. This study's 4 months is below that.
Counting every sponsor, half of 55 studies reached it within 26 months; a quarter within 13 and three quarters within 34.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Feb 2020. You cannot join it, but the record below documents what was studied.
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