An interventional study of fMRI and EEG study in Healthy Volunteers, sponsored by Hospices Civils de Lyon. Completed at 1 site in France. Open to participants aged 20 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-29.
Sponsored by Hospices Civils de Lyon · Not applicable, Interventional, and Basic science
Effective exploration of the environment, check for information to improve one's own performance, are fundamental abilities of human cognition. These abilities are dependent on the process of cognitive control.
However, they are clearly impaired and uncontrollable in certain behavioral disorders such as obsessive-compulsive disorder (OCD). Compulsive checks of these patients, spontaneously associated with a feeling of intense uncertainty, suggest disturbances of evaluative and metacognitive functions. However, no biological observations have yet been able to feed these hypotheses.
The evaluation of decisions and actions involves the middle cingulate cortex (MCC) (which belongs to a cortico-subcortical network structurally and functionally altered in OCD patients). Cingulotomy has long been used as a therapy in severe OCD, with However, the precise part of the cingulate cortex that contributes to check (and its pathological forms) remains to be discovered.
The purpose of this research campaign is to determine, through functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) in healthy human subjects:
Exclusion Criteria:
Other: fMRI and EEG study
fMRI and EEG study
Measuring changes in brain activity in regions of interest when performing cognitive tasks.
Behavior: Measurement of reaction times of correct answer during cognitive task. fMRI and EEG: Brain activity signal,
Time frame: through study completion, an average of 3 years
Measuring changes in brain activity in regions of interest when performing cognitive tasks.
Behavior: Measurement of % of correct answer during cognitive task.
Time frame: through study completion, an average of 3 years
Measuring changes in brain activity in regions of interest when performing cognitive tasks.
\- Measurement of the amplitude of the BOLD signal change in MRI according to the different cognitive tasks in the different regions of interest. Measurement of resting GABA and Glutamate concentrations in the different regions of interest. Measurement of the amplitude of the change of the electrical signal in EEG according to the different cognitive tasks in the different regions of interest.
Time frame: through study completion, an average of 3 years
Calculation of the correlations in the regions of interest of the individual values of the Blood Oxygen Level Dependent (BOLD) signal with the data of the concentration of Acide γ-aminobutyrique (GABA)
calculate with the bold signal (spectroscopy)
Time frame: through study completion, an average of 3 years
Calculation of the correlations in the regions of interest of the individual values of the Blood Oxygen Level Dependent (BOLD) signal with the data of the amplitude of the electrical signal (EEG)
Time frame: through study completion, an average of 3 years
This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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Hospices Civils de Lyon