An observational study in BECTS and Epilepsy, Rolandic, sponsored by Neuromed IRCCS. Status unknown at 1 site in Italy. Open to participants aged 6 Years to 11 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-11-02.
Sponsored by Neuromed IRCCS · Observational
The social processes depend on complex cognitive mechanisms, which involve mainly the frontal and temporal lobe regions. Patients with early onset frontal and temporal lobe lesions might later develop important deficits in social integration. Accordingly, children with early onset temporal lobe epilepsy (TLE) demonstrate altered emotion recognition.
Study design: Multicentre, Case-control study.
Emotion recognition is a first step for the development of the capacity to judge the thoughts, intentions, and desires of others. In infants, the capacity to identify, distinguish, and interpret emotions is limited, but these processes are developing rapidly and innately during the first years of life, on the same neural bases as those described in adulthood. Children with BECTS show altered social behavior. In fact, deficit in social cognition could derive from brain dysfunction in the frontotemporal regions primarily affected in BECTS, since these regions are also viewed as playing an important role in social cognition and development of social skills.
The investigators hypothesized that children with BECTS might have altered social cognitive skills and underlying neural networks.
23 studies on the registry are indexed under Epilepsy, Rolandic; 3 are open to participants now.
Browse Epilepsy, Rolandic studies →Neuromed IRCCS is the lead sponsor of 81 studies on the registry; 25 are open to participants now.
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Two samples matched for number of partecipants, sex, age range, and education. The two samples will include 200 children with BECTS diagnosis, as many healthy controls.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Children with active BECTS according to state-of-the-art diagnostic criteria of ILAE (International League Against Epilepsy). Eligible subjects will be recruited at their first clinical observation in the epilepsy centers involved in the study. All subjects will perform five diagnostic evaluations named: IDS (Intelligence and Development Scale) MMSPE (Mini Mental State Pediatric Examination) CDI 2 (Children Depression Inventory 2) CBCL (Child Behavior Check List) Tests of facial expression evaluation
Diagnostic Test: IDS;MMSPE;CDI 2;CBCL;tests of facial expression evaluation
Healthy controls matched for sex, age range, and education with no family history for epilepsy or other neuropsychiatric disorders. All subjects will perform the following tests: MMSPE (Mini Mental State Pediatric Examination) CDI 2 (Children Depression Inventory 2) CBCL (Child Behavior Check List) Tests of facial expression evaluation
Diagnostic Test: IDS;MMSPE;CDI 2;CBCL;tests of facial expression evaluation
Five pictures (including nonfacial features; i.e., hairs) were used for each emotion, giving a total of 25 trials.Stimuli consist of pictures of facial affect taken from the Ekman and Friesen series.
Number (total amount) of errors in facial emotion recognition
A neuropsychologist will sign the number of errors in recognizing each facial emotion expression
Time frame: an average of 1 year
Rating of the intensity of facial expressions
A neuropsychologist will ask the subjects to rate (on a scale from 0 = not at all to 5 = very much) each stimulus with respect to the prototypical expression of that emotion
Time frame: an average of 1 year
Rating of the arousal of facial expressions
A neuropsychologist will ask the subjects to evaluate arousal in terms of feeling of high-low energy/wakefulness/alertness by rating each stimulus on a 9-point scale.
Time frame: an average of 1 year
Rating of the valence of facial expressions
A neuropsychologist will ask the subjects to evaluate valence in terms of feeling of high-low pleasantness-unpleasantness by rating each stimulus on a 9-point scale.
Time frame: an average of 1 year
EEG abnormality lateralization and facial emotion recognition
The investigators will include in statistical analysis the side (dominant hemisphere vs. non-dominant) of EEGraphic abnormalities on awake/sleep recordings
Time frame: an average of 1 year
Start is estimated for Nov 2018; primary completion for Mar 2020, 16 months later.
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This study is status unknown, as verified in Oct 2018. You cannot join it, but the record below documents what was studied.
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Neuromed IRCCS