An interventional study of Remote ischemic preconditioning and Sham control in Platelet Dysfunction, sponsored by Seoul National University Hospital. Completed at 1 site in South Korea. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-10-15.
Sponsored by Seoul National University Hospital · Not applicable, Interventional, and Prevention
In this study, the investigators are going to investigate the effects of remote ischemic preconditioning on platelet activation in patients undergoing cardiac surgery with cardiopulmonary bypass.
Previous studies reported that remote ischemic conditioning reduce platelet activation in patients with coronary artery disease or patients undergoing ablation for atrial fibrillation. Cardiac surgery with cardiopulmonary bypass has been associated with platelet activation. In this randomized study, investigators are going to compare the effects of remote ischemic preconditioning (RIPC) on platelet activation using flow cytometry in patients undergoing cardiac surgery with cardiopulmonary bypass.
Seoul National University Hospital is the lead sponsor of 1,898 studies on the registry; 274 are open to participants now.
Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.
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Remote ischemic conditioning after anesthesia induction \- four cycles of 5 min of ischemia followed by 5 min of reperfusion by inflation to 200 mm Hg and deflation of a blood pressure cuff on the upper arm
Device: Remote ischemic preconditioning
The same blood pressure cuff is placed around the upper arm, but the cuff is inflated to 10mm Hg.
Device: Sham control
Four cycles of 5 min of ischemia, which is induced by a blood pressure cuff in the upper arm inflated to 200 mmHg, followed by 5 min of reperfusion, during which the cuff is deflated.
The same blood pressure cuff is placed around the upper arm, but the cuff is inflated to 10 mm Hg and ischemic preconditioning is not induced.
Platelet activation measured by CD62P expression using flow cytometry
CD62P AUC (area under the curve)
Time frame: During 3hour after cardiopulmonary bypass initiation
Platelet activation measured by CD63 expression using flow cytometry
CD63 AUC (area under the curve)
Time frame: During 3hour after cardiopulmonary bypass initiation
Platelet activation measured by monocyte-platelet aggregates (MPA) expression using flow cytometry
MPA AUC (area under the curve)
Time frame: During 3hour after cardiopulmonary bypass initiation
Platelet activation measured by PAC1 expression using flow cytometry
PAC1 AUC (area under the curve)
Time frame: During 3hour after cardiopulmonary bypass initiation
Platelet activation measured by platelet microparticles (PMP) expression using flow cytometry
PMP AUC (area under the curve)
Time frame: During 3hour after cardiopulmonary bypass initiation
ADPtest by Multiplate® platelet function analyser
ADPtest AU
Time frame: 3hour after cardiopulmonary bypass initiation
ASPItest by Multiplate® platelet function analyser
ASPItest AU
Time frame: 3hour after cardiopulmonary bypass initiation
COLtest by Multiplate® platelet function analyser
COLtest AU
Time frame: 3hour after cardiopulmonary bypass initiation
This study is completed, as verified in Oct 2019. You cannot join it, but the record below documents what was studied.
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