A Phase 4 interventional study of Pregabalin in Effect of Laryngoscopy and Tracheal Intubation, sponsored by Shanghai Zhongshan Hospital. Completed. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2018-03-09.
Sponsored by Shanghai Zhongshan Hospital · Phase 4, Interventional, and Treatment
The purpose of the study is to evaluate whether Pregabalin is safe and effective in stabilizing cardiovascular response to laryngoscopy and tracheal intubation of patients under general anesthesia.
Exclusion Criteria:
the patients receive routine preoperative preparation without having Pregabalin
the patients receive 150mg pregabalin 60 minutes prior to the surgery
Drug: Pregabalin
the patients receive 300mg pregabalin 60 minutes prior to the surgery
Drug: Pregabalin
the patients receive 150mg or 300mg pregabalin 60 minutes prior to the surgery
heart rate
effect of 300mg pregabalin, 150mg pregabalin premedication versus control group on the heart rate due to laryngoscopy and tracheal intubation
Time frame: heart rate 3 minutes after intubation
Mean arterial blood pressure
effect of 300mg pregabalin, 150mg pregabalin premedication versus control group on the Mean arterial blood pressure due to laryngoscopy and tracheal intubation
Time frame: baseline mean arterial blood pressure before drug administration, heart rate before intubation, heart rate after 0 minute, 1minute, 3minutes, 5 minutes, 7minutes, 10minutes after intubation and before skin incision
systolic blood pressure
effect of 300mg pregabalin, 150mg pregabalin premedication versus control group on the systolic blood pressure due to laryngoscopy and tracheal intubation
Time frame: baseline systolic blood pressure before drug administration, heart rate before intubation, heart rate after 0 minute, 1minute, 3minutes, 5 minutes, 7minutes, 10minutes after intubation and before skin incision
diastolic blood pressure
effect of 300mg pregabalin, 150mg pregabalin premedication versus control group on the diastolic blood pressure due to laryngoscopy and tracheal intubation
Time frame: baseline diastolic blood pressure before drug administration, heart rate before intubation, heart rate after 0 minute, 1minute, 3minutes, 5 minutes, 7minutes, 10minutes after intubation and before skin incision
Ramsay score
Ramsay score of 300mg pregabalin, 150mg pregabalin premedication versus
Time frame: baseline Ramsay score before drug administration and Ramsay score before intubation
Incidence of all clinical adverse events
The occurrence of dizziness, nausea, vomit and allergy
Time frame: 1hour after surgery
No study locations are listed for this record.
This study is completed, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.
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Shanghai Zhongshan Hospital