An observational study in COPD, sponsored by University of Lincoln. Completed at 3 sites in United Kingdom. Open to participants aged 40 Years to 90 Years. Per ClinicalTrials.gov, last updated 2018-10-09.
Sponsored by University of Lincoln · Observational
COPD is characterised by irreversible airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response. This inflammation can be amplified with flare-ups that are commonly seen in COPD patients. Pulmonary rehabilitation is one of the most effective methods of managing chronic obstructive pulmonary disease (COPD). Pulmonary rehabilitation has been seen to induce improvements in functional capacity and quality.
In healthy individuals, exercise has been shown to induce an anti-inflammatory response when performed regularly. However, the effects of exercise on inflammation in COPD are unclear. Our initial CIMPRES-COPD study has looked into the effects of short-term exercise, as part of pulmonary rehabilitation, on inflammation. However, this trial will examine the inflammatory response in COPD patients who are most active following pulmonary rehabilitation against those who are least active.
This study will split participants into 2 groups according to physical activity level following pulmonary rehabilitation. We will recruit 40 COPD patients who provided a sample in the initial CIMPRES-COPD study to explore inflammatory responses in those who are most active and least active. By better understanding the mechanisms of how long-term physical activity levels affects inflammation in COPD, we could design better interventions to increase physical activity levels following pulmonary rehabilitation.
COPD patients who have enrolled on pulmonary rehabilitation and took part in the initial CIMPRES-COPD study.
Exclusion Criteria:
COPD patients with higher physical activity levels as defined by daily step counts.
Other: Physical activity monitoring
COPD patients with lower physical activity levels as defined by daily step counts.
Other: Physical activity monitoring
COPD patients will wear an accelerometer and complete questionnaires related to daily physical activity levels for 7 days before returning for a clinic visit.
Cytokines
Changes in concentration of inflammatory cytokines in the plasma of all participants using ELISA's (mg/L)
Time frame: May 2018 - August 2018
Leukocyte count
Changes in total and differential leukocyte count in all participants (10\^9.L-1)
Time frame: May 2018 - August 2018
Cell function
Changes in function of the following cells: myeloperoxidase, neutrophil elastase, MMP-8, MMP-9, TNF-a in the plasma of all participants using ELISA's (mg/L)
Time frame: May 2018 - August 2018
Cell sensitivity to corticosteroids
Changes in cell sensitivity to corticosteroids and forskolin in all participants (expressed as fold increase from not treated samples)
Time frame: May 2018 - August 2018
Plan to share: No
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This study is completed, as verified in Sep 2018. You cannot join it, but the record below documents what was studied.
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University of Lincoln