An observational study in Stem Cell Transplant Complications, sponsored by University of Nebraska. Completed at 1 site in United States. Open to participants aged 60 Years to 85 Years. Per ClinicalTrials.gov, last updated 2026-01-08.
Sponsored by University of Nebraska · Observational
This study will examine how adults ≥ 60 years old thinking and memory abilities are affected by stem cell transplant; whether these changes affect day-to-day activities and quality of life and how thinking and memory abilities are affected by genetics, depression, anxiety and physical function. Genetics and other factors may affect the brain's chemicals or structure, and may increase risk for negative effects on thinking and memory.
In this study, the investigators are looking to understand: 1) how adults ≥ 60 years old thinking and memory abilities are affected by stem cell transplant; 2) whether these changes affect day-to-day activities and quality of life; and 3) how thinking and memory abilities are affected by genetics, depression, anxiety and physical function. Genetics and other factors may affect the brain's chemicals or structure, and may increase risk for negative effects on thinking and memory. Participants will undergo neurocognitive testing along with the collection of a saliva sample and completing a battery of questionnaires and assessments.
The study population is being recruited from the Fred \& Pamela Buffett Cancer Center at the University of Nebraska Medical Center.
Exclusion Criteria:
Assess differences with cognitive function in older patients undergoing allogeneic or autologous stem cell transplant at 4 timepoints.
Cognition will be measured using a neuropsychological battery.
Time frame: Before transplant; Post Transplant at 100 days, 6 months, and 12 months
Assess quality of life of of older patients undergoing allogeneic and autologous transplant at 4 timepoints.
Quality of life will be measured with the EORTC Quality of Life-30C questionnaire.
Time frame: Before transplant; Post Transplant at 100 days, 6 months, and 12 months
Assess activity engagement of older patients undergoing allogeneic and autologous transplant at 4 timepoints.
Activity engagement will be measured with the Activity Card Sort-modified.
Time frame: Before transplant; Post Transplant at 100 days, 6 months, and 12 months
Describe genetic variations in genes potentially involved in cognitive function and cancer treatment.
A saliva sample will be collected to look at genetic variations.
Time frame: 1 time collection: Before transplant
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Plan to share: No
This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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University of Nebraska