An observational study in Nutritional and Metabolic Diseases, sponsored by Mebo Research, Inc.. Completed at 2 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-10-14.
Sponsored by Mebo Research, Inc. · Observational
The purpose of this secondary analysis is to identify breath signatures associated with idiopathic malodor conditions.
Individuals with metabolic disorders may sporadically produce malodors despite good hygiene. Analysis of volatile organic compounds (VOCs) helps to gain insights into medical conditions arising due to metabolic dysfunction as different metabolic pathways emit and or consume various VOCs. These VOCs can be detected via the exhaled breath collected and analyzed with a portable breath collection apparatus. VOC profiles will be compared with self-reported symptoms and other observations of participating subjects.
Individuals self-reporting idiopathic malodor production as a consequence of a systemic disorder
Exclusion Criteria:
individuals self-reporting idiopathic body odor with or without bad breath
Other: Breath test
individuals self-reporting idiopathic bad breath but no body odor
Other: Breath test
Breath samples taken from all participants, analyzed with gas chromatography mass spectrometry (GC/MS), no treatment given.
Also known as: Exhaled breath metabolomics
VOCs detected
Expired air sample drawn principally from alveolar breath is analyzed by gas chromatography-mass spectrometry. Chromatograms are searched against the NIST library. The response for each analyte is normalized by using internal standards containing 1-bromo-4-fluoro-benzene.
Time frame: 2 years
Correlations between breath biomarkers and self-reported observations (questionnaires)
VOC profiles will be compared with self-reported symptoms, observed exposures and other observations of participating subjects. Volatile organic compounds differentiating the disease activity will be identified.
Time frame: 1 year
This study is completed, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.
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Mebo Research, Inc.