CClinicalTrials.gg
WithdrawnNCT03447405Updated Feb 7, 2024

Dino Egg in Neonatal Intensive Care Unit

An interventional study of Dino Egg in Premature Birth, sponsored by Jonathan Slaughter. Withdrawn at 1 site in United States. Open to participants aged 32 Weeks to 34 Weeks. Per ClinicalTrials.gov, last updated 2024-02-07.

Sponsored by Jonathan Slaughter · Not applicable, Interventional, and Prevention

Why this study was withdrawn
Grant not funded
Phase
Not applicable
Study type
Interventional
Enrollment
0
Allocation
Non-randomized
Ages
32 Weeks to 34 Weeks
Sex
All
01

Study summary

Dino EGG mother's voice exposure and multisensory processing in Neonatal Intensive Care Unit infants.

This is a 2 phase prospective comparative effectiveness trial of our parents' voice intervention with 290 hospitalized preterm infants.

As a part of a previous project, an early technology development award from the Nationwide Children's Hospital (NCH) Technology Office allowed us to develop 10 functioning prototypes of the DINO EGG speakers, a NICU-safe and developmentally appropriate music player that delivers parent's voice to the bedside of NICU infants. The device passed NCH NICU-safe products committee and has been used in the clinical setting delivering clinical music therapy services (available at bedside to play parents' voice).

The first phase of the current study is to test an updated prototype version of the device that replicates a previously FDA (and NCH NICU-safe products) proved device called Pacifier Activated Lullaby (PAL), used and described in IRB15-01035, but being discontinued by the company. The discontinuation is not due to safety or health benefits concerns. Therefore, no device available on the market currently exists to accomplish NICU parents' voice delivery in a consistent and safe manner, the investigators modified a 510K-approved feeding device that is no longer available and whose intellectual property rights have expired. The device's air displacement sensor, which fits into a standard NICU pacifier, allowed the investigators to deliver processed and developmentally appropriate recordings of parent's voice, contingent upon the infant producing effort to receive it. Intellectual property rights were filed for the modifications and use process through the technology transfer and legal office at NCH.

Therefore, phase I will test the usability of the device (safety for the NICU was confirmed), not the effectiveness of the parents' voice delivery for the infant. Parent and nursing questionnaires about the importance of the device availability and its usability will be collected from parents and Registered Nurse (RN) staff that choose to provide the feedback.

02

Conditions studied

  • Premature Birth

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Keywords

  • Music Therapy
  • NICU
  • Infants
  • multisensory processing
03

Who can participate

Ages eligible
32 Weeks to 34 Weeks
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Inclusion criteria will be Post Menstrual Age (PMA) 32 0/7-34 6/7.

Exclusion criteria

Exclusion Criteria:

  • Ventilation using an endotracheal tube
  • Major congenital malformations
  • Family history of genetic hearing loss
  • Use of sedatives or seizure medications
  • Presence of severe neural injury on neuroimaging (intraventricular hemorrhage grade II or IV, periventricular leukomalacia, cerebellar hemorrhage, ischemic or thrombotic injury)
  • Presence of systemic inflammatory conditions (history of necrotizing enterocolitis Bell's stage IIA or above or culture-documented sepsis or meningitis).
04

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
0 participants (actual)

Study arms

  • Experimental
    Dino Egg Safety and useability

    Test the usability of the device (safety for the NICU was confirmed), not the effectiveness of the parents' voice delivery for the infant. Parent and nursing questionnaires about the importance of the device availability and its usability will be collected from parents and RN staff that choose to provide the feedback.

    Device: Dino Egg

  • No intervention
    Standard of Care

Interventions

  • DeviceDino Egg

    DINO EGG speakers, a NICU-safe and developmentally appropriate music player that delivers parent's voice to the bedside of NICU infants. The device passed NCH NICU-safe products committee and has been used in the clinical setting delivering clinical music therapy services (available at bedside to play parents' voice).

05

What researchers measure

Primary outcomes

  1. Usability of the device through questionaires

    We will confirm a larger scale that for preterm infants, standardized exposure to mother's voice with a contingent stimulus of non-nutritive sucking can improve the development of speech sound discrimination in the NICU. Phase I will test the usability of the device (safety for the NICU was confirmed), not the effectiveness of the parents' voice delivery for the infant. Parent and nursing questionnaires about the importance of the device availability and its usability will be collected from parents and RN staff that choose to provide the feedback.

    Time frame: Through end of study completion, an average of 1 year

06

Study locations

1 site
  • Nationwide Children's Hospital
    Columbus, Ohio 43205, United States
07

Registry details

Key details

Study ID
NCT03447405
Lead sponsor
Jonathan Slaughter
Responsible party
Jonathan Slaughter (Principal Investigator, Nationwide Children's Hospital) — Sponsor-investigator
First posted
Feb 27, 2018
Start date
Jul 1, 2019 (estimated)
Primary completion
Jan 1, 2024 (estimated)
Completion
Jan 1, 2024 (estimated)
Last update
Feb 7, 2024

Study contacts

Nathalie L Maitre, MD,PHD
principal investigator · Nationwide Children's Hospital

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is withdrawn, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.

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