An interventional study of Mannitol in Supratentorial Tumors, sponsored by Huashan Hospital. Completed at 1 site in China. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2020-11-20.
Sponsored by Huashan Hospital · Not applicable, Interventional, and Other
Although mannitol is used for brain relaxation during neurosurgery and in the treatment of raised intracranial pressure; there is not a consensus on its safe, effective dose and the duration of its administration. This study aimed to compare the effects of the mannitol in different use times, on the brain relaxation, electrolyte, lactate levels of the blood, peroperative fluid balance and the volume of the urine in supratentorial mass resection surgeries.
22 studies on the registry are indexed under Supratentorial Neoplasms; 3 are open to participants now.
This study's enrollment of 100 is above the median of 80 across 20 interventional studies indexed under Supratentorial Neoplasms.
Browse Supratentorial Neoplasms studies →Huashan Hospital is the lead sponsor of 247 studies on the registry; 104 are open to participants now.
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in this group, Mannitol (1.0g/kg) is given just after the induction of general anesthesia
Drug: Mannitol
in this group, Mannitol (1.0g/kg) is given at the time of skin incision
Drug: Mannitol
This drug is in our routine use of neuroanesthesia, are given for facilitate brain relaxation
brain relaxation score
difference in brain relaxation after drug administration The assessment was performed using a 4-point scale, 1 denoting bulging or the condition that additional methods for brain relaxation are immediately and always required in order to continue the surgical procedure because of brain swelling; 2, firm or the condition that additional methods for brain relaxation are occasionally required to continue the surgical procedure; 3, adequate; 4, perfectly relaxed. In all patients, the degree of brain relaxation was assessed at the time of dural opening and satisfactory brain relaxation was defined as a brain relaxation score of 3 or 4. All the Secondary Outcome Measures below are observed the safety for intraoperative brain debulking during elective supratentorial craniotomy
Time frame: just before dural opening
Blood sodium levels
Time frame: change in 30 minute intervals in the first 2 hour after study drug administration
Blood potassium levels
Time frame: change in 30 minute intervals in the first 2 hour after study drug administration
Blood chlorine levels
Time frame: change in 30 minute intervals in the first 2 hour after study drug administration
Blood lactate levels
Time frame: change in 30 minute intervals in the first 2 hour after study drug administration
Fluid balance during operation
Time frame: change in 30 minute intervals in the first 2 hour after study drug administration
Plan to share: Undecided
No publications or documents are linked to this record.
Ran from Mar 2018 to primary completion in Mar 2019, 12 months.
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This study is completed, as verified in Nov 2020. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Mannitol