CClinicalTrials.gg
CompletedNCT03443687SQEASIUpdated Dec 21, 2023Results posted

Systematized Quality Exercise Alternatives for Stress Incontinence

An interventional study of Pelvic Floor Physical Therapy and Home Biofeedback in Stress Urinary Incontinence, Pelvic Floor; Weak and Incontinence, Urinary, sponsored by University of New Mexico. Completed at 1 site in United States. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-12-21.

Sponsored by University of New Mexico · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
54
Allocation
Randomized
Ages
18 Years and older
Sex
Female
01

Study summary

This randomized controlled study evaluates the effect of home biofeedback compared to pelvic floor physical therapy for the treatment of stress urinary incontinence. Half of the participants will use a home biofeedback device for 3 months and the other half will attend pelvic floor physical therapy appointments for 3 months.

Read the detailed description

Biofeedback has been shown to be highly effective the treatment of stress urinary incontinence when used in conjunction with pelvic floor physical therapy under the instruction of a healthcare provider. Home biofeedback has not been well studied, even though several FDA cleared devices are on the market and available for patients to purchase. It is unclear if the biofeedback improves women's urinary incontinence, or if the increased contact with a healthcare provider causes the improvement.

Using a home biofeedback device, a woman places the device in her vagina and contracts the muscles of her pelvic floor to improve the strength, which can improve or cure incontinence when performed over time. Typically it takes 3 months for benefit to be seen.

02

Conditions studied

  • Stress Urinary Incontinence
  • Pelvic Floor; Weak
  • Incontinence, Urinary
  • Quality of Life
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
Female
Accepts healthy volunteers
Yes

Inclusion criteria

  • Female Subjects >18 years of age
  • SUI or Mixed UI with stress predominant symptoms and more bother by the SUI
  • English speaking/reading
  • Own a smartphone that can support phone application and Bluetooth for the biofeedback device
  • Willing to come for 4 PFPT visits over 3 months if randomized

Exclusion criteria

Exclusion Criteria:

  • Prior anti-incontinence surgery
  • Had prior pelvic floor physical therapy for SUI
  • Prolapse of any compartment noted below the hymen
  • Inability to speak/understand English
  • Pregnant
  • Decline or unable to return for frequent PT visits during study period
  • Unable to be contacted for follow up by telephone
  • Neurologic disorders known to cause neurogenic bladder
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
54 participants (actual)

Study arms

  • Active comparator
    Pelvic Floor Physical Therapy

    If randomized to this arm, women will complete demographic forms and questionnaires. They will then undergo the intervention of 4 pelvic floor physical therapy visits over 3 months. At that time they will return for a follow up visit and complete questionnaires.

    Behavioral: Pelvic Floor Physical Therapy

  • Experimental
    Home Biofeedback

    If randomized to this arm, women will complete demographic forms and questionnaires. They will then be given a pelvic floor exercise device that is bluetooth linked to a smartphone application. They will be instructed on how to use the device daily for 3 months and their intervention will be to perform daily exercises with the device in place. At 3 months they will return for a follow up visit and complete questionnaires.

    Device: Home Biofeedback

Interventions

  • BehavioralPelvic Floor Physical Therapy

    Pelvic floor exercises for 3 months under instruction of physical therapist

    Also known as: PFPT

  • DeviceHome Biofeedback

    Pelvic floor exercises for 3 months using biofeedback device

    Also known as: PeriCoach Kegel Exerciser

05

What researchers measure

Primary outcomes

  1. Change in Quality of Life

    Scale is International Consultation Incontinence Questionnaire short form (ICIQ-SF). Minimum is 0 and Maximum is 21. A higher score indicates greater impairment from incontinence.

    Time frame: 3 months

Secondary outcomes

  1. Sexual Function

    Female sexual index will be used to assess change in sexual function over study. Female sexual function index (FSFI) questionnaire and Pelvic organ prolapse incontinence sexual questionnaire were PI developed questionnaires. The minimum is 0 and the maximum is 36. A higher score indicates greater sexual impairment.

    Time frame: 3 Months

06

Results

Posted Dec 21, 2023

Participant flow

Participant flow — Overall Study
MilestonePelvic Floor Physical TherapyHome Biofeedback
Started2727
Completed2221
Not completed56
Withdrew: Lost to follow-up35
Withdrew: Withdrawal by subject10
Withdrew: Discontinued intervention11

Outcome measures

PrimaryChange in Quality of Life

Scale is International Consultation Incontinence Questionnaire short form (ICIQ-SF). Minimum is 0 and Maximum is 21. A higher score indicates greater impairment from incontinence.

Time frame:
3 months
Reported as:
Mean · score on a scale
Change in Quality of Life
score on a scalePelvic Floor Physical TherapyHome Biofeedback
Change in Quality of Life4.73 (3.21 to 6.25)3.95 (2.21 to 5.70)
SecondarySexual Function

Female sexual index will be used to assess change in sexual function over study. Female sexual function index (FSFI) questionnaire and Pelvic organ prolapse incontinence sexual questionnaire were PI developed questionnaires. The minimum is 0 and the maximum is 36. A higher score indicates greater sexual impairment.

Time frame:
3 Months
Reported as:
Mean · score on a scale
Sexual Function
score on a scalePelvic Floor Physical TherapyHome Biofeedback
Sexual Function0.42 (0 to 36)1.81 (0 to 36)

Adverse events

Collected over 3 months. Non-serious events are listed at a 3% frequency threshold.

Adverse event summary by group
GroupDeathsSeriousOther
Pelvic Floor Physical Therapy0/27 (0%)0/27 (0%)4/27 (14.8%)
Home Biofeedback0/27 (0%)0/27 (0%)1/27 (3.7%)
Most frequent other events
Most frequent other events
EventPelvic Floor Physical TherapyHome Biofeedback
infectionInfections and infestations2/270/27
vaginal infectionInfections and infestations1/271/27
Vaginal discharge without infectionInfections and infestations1/270/27

Baseline characteristics

Age, Continuous
Age, Continuous(years)Pelvic Floor Physical TherapyHome BiofeedbackTotal
Mean48 ± 1344 ± 1046 ± 2
Sex: Female, Male
Sex: Female, Male(Participants)Pelvic Floor Physical TherapyHome BiofeedbackTotal
Female272754
Male000
Race (NIH/OMB)
Race (NIH/OMB)(Participants)Pelvic Floor Physical TherapyHome BiofeedbackTotal
American Indian or Alaska Native101
Asian000
Native Hawaiian or Other Pacific Islander000
Black or African American000
White141125
More than one race91019
Unknown or Not Reported369
07

Study locations

1 site
  • University of New Mexico
    Albuquerque, New Mexico 87131, United States
08

References and documents

Publications

  • Barnes KL, Cichowski S, Komesu YM, Jeppson PC, McGuire B, Ninivaggio CS, Dunivan GC. Home Biofeedback Versus Physical Therapy for Stress Urinary Incontinence: A Randomized Trial. Female Pelvic Med Reconstr Surg. 2021 Oct 1;27(10):587-594. doi: 10.1097/SPV.0000000000000993. PubMed 33208658 ↗

Study documents

  • Protocol and statistical analysis plan · Oct 1, 2018
  • Informed consent form · Jul 18, 2018

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: No

09

Registry details

Key details

Study ID
NCT03443687
Lead sponsor
University of New Mexico
Responsible party
Gena Dunivan (Associate Professor, University of New Mexico) — Principal investigator
First posted
Feb 23, 2018
Start date
Jun 1, 2018
Primary completion
Mar 3, 2020
Completion
Mar 3, 2020
Results posted
Dec 21, 2023
Last update
Dec 21, 2023

Study contacts

Gena Dunivan, MD
principal investigator · University of New Mexico HSC, Department of Obstetrics and Gynecology

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Dec 2023. You cannot join it, but the record below documents what was studied.

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