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CompletedNCT03431389PITSUpdated Feb 13, 2018

"Outcomes of Tracheostomy Done for Patients Admitted in Anesthesia Intensive Care Units of Assiut University Hospital"

A Phase 2/3 interventional study of Tracheostomy tube in Tracheostomy Complication, sponsored by Assiut University. Completed at 1 site in Egypt. Open to participants aged 1 Year to 79 Years. Per ClinicalTrials.gov, last updated 2018-02-13.

Sponsored by Assiut University · Phase 2/3, Interventional, and Treatment

Phase
Phase 2/3
Study type
Interventional
Enrollment
81
Allocation
Randomized
Ages
1 Year to 79 Years
Sex
All
01

Study summary

This study was undertaken to Identify the factors affecting the outcomes of tracheostomy done in ICU for patients subjected to prolonged intubation and ventilation and to suggest guidelines to control:

  1. proper timing of tracheostomy
  2. process of decannulation.
Read the detailed description

Tracheostomy is described as the creation of a stoma at the skin surface which leads into the trachea. From the first tracheostomy until about 1930, the operation was performed exclusively for laryngeal obstruction. Nowadays, due to the development of the care of critically ill patients in intensive care units (ICUs), there are other indications for the procedure including prolonged intubation and pulmonary toilet.

The initial management of patients in an intensive care unit involves a series of interventions that aim to stabilize and then optimize their physiological state. Mechanical ventilation (MV) is a commonly utilized intervention to support a patient's respiratory function. The second phase in ICU management focuses on weaning the patient from the artificial supportive mechanisms.

The principle role of tracheostomy in the ICU is to expedite the weaning process in patients requiring prolonged mechanical ventilation and those predicted to be at risk of pulmonary aspiration. Tracheostomy facilitates weaning primarily by allowing increased level of patient activity and mobility.

Tracheostomy protects the larynx and the upper airway from prolonged intubation which may lead to laryngotracheal stenosis. Patients with tracheostomies tend to have fewer days of mechanical ventilation because of the improvements in the respiratory physiology. This is especially in trauma patients. They have improved secretion clearance as suction is easy and less strength is required for expectoration. This may be linked to the lower incidence of pneumonia and respiratory infections seen, especially in trauma victims.

Patients with tracheostomy are less sedated and therefore able to move in bed. The patients may also be able to swallow, so may be started on oral feeding sooner and mouth care is easier compared with an endotracheal tube (ETT) tube.

02

Conditions studied

  • Tracheostomy Complication
03

Who can participate

Ages eligible
1 Year to 79 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • All patients who were admitted to the ICUs of the main Assiut University Hospital.
  • mechanically ventilated and
  • underwent tracheostomy during his/her stay in ICU.

Exclusion criteria

Exclusion Criteria:

  • Patients who were admitted to ICUs and didn't need tracheostomy during the period of admission in ICU or after discharge from ICU,
  • Patients who died during admission in ICUs before being tracheostomized,
  • Patients who died during admission in ICUs after being tracheostomized and the cause of death was not related to the tracheostomy procedure or care.
04

Study design

Phase
Phase 2 / Phase 3
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
81 participants (actual)

Study arms

  • Active comparator
    Decannulated group

    Decannulation was considered when the patients were no longer in need for tracheostomy tube and fulfilled the criteria of decannulation: No need for mechanical ventilation, no chocking with oral intake, no chest infection, effective cough reflex, laryngeal examination show bilateral mobile vocal cords with sufficient gap. Trial of decannulation was considered successful, if there was no need to reapply tracheostomy within 6 months of decannulation.

    Device: Tracheostomy tube

  • Active comparator
    Failure of decannulation group

    Decannulation was considered when the patients were no longer in need for tracheostomy tube and fulfilled the criteria of decannulation: No need for mechanical ventilation, no chocking with oral intake, no chest infection, effective cough reflex, laryngeal examination show bilateral mobile vocal cords with sufficient gap. Decannulation trail was considered failed if there was a need to reapplication of tracheostomy at the time of decannulation or within six months of decannulation the duration of follow up.

    Device: Tracheostomy tube

Interventions

  • DeviceTracheostomy tube

    Tracheostomy done to all patients by open surgical technique and was done in ICUs without need to transfer to theatre.

    Also known as: TT

05

What researchers measure

Primary outcomes

  1. Successful decanulation

    Trial of decannulation was considered successful, if there was no need to reapply tracheostomy within 6 months of decannulation.

    Time frame: 6 month

06

Study locations

1 site
  • Assiut university main hospital, ICUs
    Assiut, Assiut Governorate 715715, Egypt
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03431389
Lead sponsor
Assiut University
Responsible party
Hala Saad Abdel-Ghaffar (Professor of anesthesia and intensive care, faculty of medicine, Assiut university., Assiut University) — Principal investigator
First posted
Feb 13, 2018
Start date
Jun 1, 2015
Primary completion
May 31, 2016
Completion
May 31, 2016
Last update
Feb 13, 2018

Study contacts

Hala S Abdelghaffar, MD
principal investigator · Professor in anesthesia and intensive care department, faculty of medicine, Assiut university, Egypt.

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

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