An interventional study of MCO-HD and high-flux HDF in Chronic Kidney Diseases and Uremia, sponsored by Region Skane. Withdrawn. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-04-15.
Sponsored by Region Skane · Not applicable, Interventional, and Treatment
The medium cut-off dialysis (MCO) membrane has been developed to improve middle molecule removal compared to standard high-flux dialysis filters.
The aim of this study is to compare levels of middle molecules after 12 weeks of MCO hemodialysis, compared to 12 weeks of hemodiafiltration using standard high-flux filter.
3,090 studies on the registry are indexed under Renal Insufficiency, Chronic; 698 are open to participants now.
Browse Renal Insufficiency, Chronic studies →Region Skane is the lead sponsor of 386 studies on the registry; 122 are open to participants now.
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Exclusion Criteria:
Hemodialysis with Medium Cut-Off filter
Device: MCO-HD · Device: high-flux HDF
Hemodiafiltration with standard high-flux filter
Device: MCO-HD · Device: high-flux HDF
Measurements will be done after 0,4,8 and 12 weeks of hemodialysis with Medium Cut-Off filter.
Measurements will be done after 0,4,8 and 12 weeks of hemodiafiltration with standard high-flux filter
Comparison of predialysis mean of middle molecules after 12 weeks (Beta-2-microglobulin, Cystatin C, Myoglobin, Beta-Trace Protein, Troponin T, Prealbumin).
Time frame: 12 weeks
Comparison of postdialysis mean of middle molecules after 12 weeks (Beta-2-microglobulin, Cystatin C, Myoglobin, Beta-Trace Protein, Troponin T, Prealbumin).
Time frame: 12 weeks
Comparison of predialysis mean of small molecules (CRP, Urea, Phosphate and Creatinine) after 12 weeks.
Time frame: 12 weeks
Comparison of postdialysis mean of of small molecules (CRP, Urea, Phosphate and Creatinine) after 12 weeks.
Time frame: 12 weeks
Comparison of predialysis mean of large molecules after 12 weeks (Albumin, Transferrin, IgG).
Time frame: 12 weeks
Comparison of postdialysis mean of large molecules after 12 weeks (Albumin, Transferrin, IgG).
Time frame: 12 weeks
Comparison of pre- and postdialysis mean of all molecules at 0, 4 and 8 weeks.
Time frame: 8 weeks
Comparison of number of adverse effects during the study period.
Time frame: 12 weeks
Comparison of mean nPCR after 12 weeks.
Time frame: 12 weeks
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Feb 2019; primary completion for Dec 2019, 10 months later.
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This study is withdrawn, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.
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Renal Insufficiency, Chronic →