An interventional study of Beverage consumption and Daily reading in Retinal Microcirculation Disorder, sponsored by Jiannan Huang. Completed at 1 site in China. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-04-17.
Sponsored by Jiannan Huang · Not applicable, Interventional, and Basic science
The daily behaviors such as drinking coffee, wine, reading, exercise and body postural changes may have influence on the function or morphology of the retinal microcirculation in healthy people.A recent study found that the fingertips microvascular bed constricted obviously after the intake of a cup of coffee with caffeine, it significantly reduced blood flow to the fingers; Long reading of electronic products can induce significant dry eye symptoms, affect visual quality, and cause asthenopia. Microcirculation is critical for regulating vascular resistance and blood flow in organs. Fundus blood vessels is the only visible microvascular in vivo, its morphology and function changes not only associated with eye disease, but also with cardiovascular and cerebrovascular diseases. Optical coherence tomography angiography (OCTA) is a new technique which could acquire blood flow information in a non-invasive way without the use of dye. Magnetic resonance imaging (MRI) can quantitatively evaluation of cerebral blood flow and retina-choroid blood flow using the noninvasive arterial spin labeling technique in a large field of view (FOV) without depth limitations.The study tried to detect the influence of daily behaviors such as drinking coffee, red wine, reading , exercise, etc. on the retinal microcirculation with OCTA and MRI, and provide reference for health behaviors.
Jiannan Huang is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
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Exclusion Criteria
Drink 300ml red wine (alcohol concentration:12.5%), 300ml coffee (caffeine concentration 72 mg), 300 ml Baijiu (Chinese liquor, alcohol concentration:12.5%) , SipSparkTM Probiotics (facilitates ethanol degradation) was taken 0.5 hour prior to Baijiu consumption, or 300ml water.
Behavioral: Beverage consumption
Reading paper books, playing video games with mobile phones, or non-reading.
Behavioral: Daily reading
Exercise and body postural changes.
Behavioral: Body motion
The participants drink 300ml wine (alcohol concentration:12.5%)or 300ml coffee (caffeine concentration 72 mg), or water.
Reading paper books, playing video games with mobile phones, or non-reading for 8 hours.
Exercise or body postural changes
Vessel diameter index (VDI)
VDI is calculated using both the vessel area map and the skeletonized vessel map, to yield the averaged vessel caliber.
Time frame: 3 weeks
Vessel area density (VAD)
VAD is calculated as a unit-less ratio of the total image area occupied by the vasculature to the total image area in the binary vessel maps.
Time frame: 3 weeks
Flow impairment region (FIR)
FIZ: calculated by summing all 'no-flow' pixels up.
Time frame: 3 weeks
Retina-choroid blood flow
Blood flow for the entire retinal thickness were determined as a function of the distance from the optic nerve head, where the blood flow was measured at the peaks of the projection profiles. An region of interest outlining the posterior retina with a size of 0.7 to 0.8 mm across the retina-choroid thickness in the parafoveal region was used to obtain the blood flow signal time courses and averaged the values.
Time frame: 3 weeks
Cerebral blood flow (CBF)
The frontal lobe was selected as the region of interest (ROI) to measure and average the changes in CBF
Time frame: 3 weeks
Plan to share: No — No plan to share individual participant data because of personal privacy.
Ran from May 2017 to primary completion in Oct 2020, 41 months.
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This study is completed, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.
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Jiannan Huang