An observational study in Esophageal Atresia, sponsored by Hospital El Cruce. Completed at 1 site in Argentina. Open to participants aged 12 Years and older. Per ClinicalTrials.gov, last updated 2018-01-31.
Sponsored by Hospital El Cruce · Observational
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EA is one of the most frequent birth defects, with an incidence of 1 in 3000 live births1. Until the 1950s, these patients had 100% mortality; nowadays, the survival rate is greater than 90%, and only those with associated severe malformations die1-5.
Type C EA (atresia of the esophageal proximal segment with tracheoesophageal fistula between the trachea and the distal segment) is the most common variant, since it is present in 85% of the cases6-8. There is evidence that the esophageal motor disorder present in these children is secondary to a congenital neuromuscular disorder and a postoperative disorder9-14. Patients that survive the operation have greater risk of developing gastroesophageal reflux disease (GERD), caused by anomalies in the esophageal motility and its resulting delay in the evacuation of acid of the esophageal lumen.
There was a hypothesis that suggested that motility alteration could contribute to dysphagia and to the high prevalence of gastroesophageal reflux in these patients15-18. Also, there were reports of a greater incidence of severe esophagitis with requirement of fundoplication, which shows a larger failure rate17-18. Esophageal dysmotility has been proved in children with EA through performance of conventional perfusion manometry.
Lemoine C et al described three motility alteration patterns with HRM in children with repaired EA. Said study allowed a more precise knowledge of segmental esophageal motility19. Currently, there are no reports exclusively made about teenagers with repaired EA that describe segmental esophageal motility with HRM.
37 studies on the registry are indexed under Esophageal Atresia; 12 are open to participants now.
This study's enrollment of 10 is below the median of 50 across 19 observational studies indexed under Esophageal Atresia.
Browse Esophageal Atresia studies →Hospital El Cruce is the lead sponsor of 15 studies on the registry; 6 are open to participants now.
Counted across the registry records on this site, refreshed daily.
teenagers with esophageal atresia and surgically repaired
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teenagers of more than 12 years old, with repaired EA, orally fed during the last 6 months, with no history of esophageal blockage or dilations, who underwent a HREM
Exclusion Criteria:
Patterns of High Resolution Manometry in teenagers with esophageal atresia
Number of patients with patterns of complete aperistalsis, pressurization and distal esophageal contraction in High Resolution Manometry
Time frame: one day
Plan to share: No
No publications or documents are linked to this record.
Ran from Jun 2017 to primary completion in Sep 2017, 3 months.
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This study is completed, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.
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Hospital El Cruce