An observational study in Uterine Atony, sponsored by Baylor Research Institute. Completed at 1 site in United States. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-26.
Sponsored by Baylor Research Institute · Observational
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Among 10 studies in Uterine Inertia with a site in United States — 1 open to participants now, 1 under way, none of them phase 3. Uterine Inertia · United States.
Among the 10 studies in Uterine Inertia with a site in United States, this one is the only one that started in 2018, is the only observational one, and was the 5th registered.
39 studies on the registry are indexed under Uterine Inertia; 7 are open to participants now.
Browse Uterine Inertia studies →1 of the 10 studies in Uterine Inertia with a site in United States is open now. Recruiting first, the newest first:
University of Michigan · Sites in United States
Ages 18+ · Women only
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 3 Uterine Inertia studies recruiting now, 2 set no upper age limit and 1 stops at 75 or younger; none take children under 18; 1 takes healthy volunteers.
This study: 18 Years and older · female · healthy volunteers too.
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10 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 2 · Phase 2 2 · Phase 3 1 · Phase 4 4
First in 2008; this study’s year is marked. 1 started in 2018.
Median enrollment 120 across the 9 interventional studies, 21 across the 1 observational. Of the 8 that completed or were terminated, 7 (88%) have results posted.
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None of the 10 has an industry lead sponsor. The 7 most frequent:
Baylor Research Institute is the lead sponsor of 223 studies on the registry; 48 are open to participants now.
Of its 23 completed or terminated interventional studies of FDA-regulated products, 9 (39%) have results posted.
Baylor Research Institute has 3 studies filed under Uterine Inertia — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 10 studies in Uterine Inertia with a site in United States, from their registry updates:
Nothing recorded among them since 2026-09-25.
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The primary objective of this study is to determine whether there are markers in the tissue of atonic uteri, and in the patients' plasma that would help identify patients likely to suffer postpartum hemorrhage due to uterine atony. We also will attempt to identify the cause(s) of uterine atony that might suggest mechanisms to prevent and manage it.
Patient will be recruited from those admitted to our Labor and Delivery unit. Ten women will be the control subjects, and these will be selected from patients who are admitted for scheduled cesarean delivery. Ten women will be selected from women who develop uterine atony either following cesarean delivery, or postpartum patients who delivered vaginally but subsequently required surgical management of uterine atony (hysterectomy or uterine saving surgery). From each patient a small amount of uterine muscle will be excised and placed in a fixative, preservative transport medium. Ten cubic centimeters of blood will be drawn from each patient to accompany the tissue. The tissue and blood will be processed and analyzed to identify differences in the tissue and plasma of messenger RNA, micro RNA, long non-coding RNA, and DNA methylation in normal and atonic uterine patients. Statistical analysis of these markers will be performed to determine whether there are significant differences in their expression. It is hoped that differences will be discovered that may be used diagnostically to predict uterine atony, and differences that may suggest the etiology of uterine atony.
Patients recruited for the study will be pregnant women, 18 years of age or older who are laboring in Labor and Delivery, or who plan to have a scheduled cesarean section.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
patients who are admitted for repeat cesarean delivery with bilateral tubal ligation who do not develop uterine atony
Other: Analysis of genomic markers in uterine atony
Patients who develop uterine atony either during cesarean delivery or who require surgical management of atony after delivery
Other: Analysis of genomic markers in uterine atony
No intervention will be performed. We will be analyzing tissue and blood samples only to identify potential association of genomic markers with uterine atony.
Identification of genomic markers that can predict uterine atony
To extract RNA from serum and uterine tissue samples and use Next Generation miRNA Sequencing followed by quantification of serum miRNA and miRNA isoform expression using TaqMan miRNA assays and NanoString.
Time frame: 6-12 months
Identification of genomic markers that can predict uterine atony (2)
Following extraction of miRNA, to use Optical Liquid Stamping technology to analyze various miRNA isoforms in the uterine tissue and serum of subjects with normal uteri compared to atonic uteri.
Time frame: 6-12 months
Identification of genomic markers that can predict uterine atony (3)
To isolate DNA using QIAAMp DNA mini kits from uterine tissue and serum samples from subjects with atonic uteri and normal uteri and to then sequence the DNA using HiSeq Genome Analyzer. We will identify the sequence reads using Illumina base-calling software and analyze them using Zymo research proprietary analysis pipeline to identify differences in genomic expression in subjects with normal uteri compared to atonic uteri.
Time frame: 6-12 months
Plan to share: No
Ran from Feb 2018 to primary completion in Jul 2020, 28 months.
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This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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