An interventional study of Exercise. in Osteo Arthritis Knee, sponsored by Bispebjerg Hospital. Completed at 1 site in Denmark. Open to participants aged 40 Years to 90 Years. Per ClinicalTrials.gov, last updated 2019-09-25.
Sponsored by Bispebjerg Hospital · Not applicable, Interventional, and Basic science
Among 16 studies in Motor Activity by Bispebjerg Hospital — 2 open to participants now, 3 under way, none of them phase 3. Motor Activity · Bispebjerg Hospital.
Among the 16 studies in Motor Activity by Bispebjerg Hospital, this one is the 13th largest by enrollment of the 13 interventional ones that give a count, is the only one that started in 2018, is one of 11 with no phase, and was the 12th registered.
9,798 studies on the registry are indexed under Motor Activity; 1,910 are open to participants now.
Browse Motor Activity studies →2 of the 16 studies in Motor Activity by Bispebjerg Hospital are open now, in 3 countries. Recruiting first, the newest first:
Bispebjerg Hospital · Sites in Denmark, Faroe Islands, Greenland
Bispebjerg Hospital · Sites in Denmark
By country, each count listing its studies:
Of the 1,201 Motor Activity studies recruiting now, 517 (43%) set no upper age limit and 535 (45%) stop at 75 or younger; 180 take children under 18; 420 take healthy volunteers.
This study: 40 Years to 90 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
16 studies; the count open now beside each. This study's row is marked.
First in 1983; this study’s year is marked. 1 started in 2018.
This study's enrollment of 32 is below the median of 60 across 8,388 interventional studies indexed under Motor Activity.
Median enrollment 152 across the 13 interventional studies, 1,514 across the 2 observational. Of the 11 that completed or were terminated, 0 (0%) have results posted.
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Bispebjerg Hospital is the lead sponsor of 289 studies on the registry; 29 are open to participants now.
None of the studies under way reaches primary completion within a year.
Among the 16 studies in Motor Activity by Bispebjerg Hospital, from their registry updates:
Nothing recorded among them since 2026-09-25.
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This study will examine the effect of exercise on the turnover of collagen in articular cartilage and the content of cytokines in the synovial fluid from human adults with osteoarthritis.
By using stabile isotope labelling, this study will track the formation and destination of newly formed cartilage collagen in adult humans scheduled for knee replacement surgery due to osteoarthritis. The collagen formation as well as the effect on the cytokine content of the synovial fluid will be examined both at rest and in response to 4 weeks of exercise/training. Overall the project aims to improve the basic understanding of cartilage development and function in relation to osteoarthritis prevention.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Behavioral: Exercise.
Moderate to heavy intensity resistance exercise consisting of leg press.
Collagen synthesis in articular cartilage
By using incorporation of stabile isotope tracers measured by gas chromatography, the concentration of newly formed collagen will be measured.
Time frame: End of study at 4 weeks
Cytokine and enzymes concentration in synovial fluid
By using Enzyme-Linked Immunosorbent Assay (ELISA) the concentration of cytokines in synovial fluid will be measured.
Time frame: End of study at 4 weeks
Cytokine and enzymes concentration in blood
By using Enzyme-Linked Immunosorbent Assay (ELISA) the concentration of cytokines in the blood will be measured.
Time frame: At the beginning and at the end of the study at 4 weeks
Gene expression
By using real time reverse transcriptase polymerase chain reaction (RT-PCR) the concentration of messenger ribonucleic acid (mRNA) in cartilage tissue will be measured.
Time frame: End of study at 4 weeks
Strength
By calculating the total volume of weight lifted (kg) the strength will be measured.
Time frame: At the beginning and at the end of the study at 4 weeks
Body mass index (BMI)
BMI measured as the total body weight divided by the height squared (kg/m\^2)
Time frame: At the beginning of the study.
Age
The age measured in years
Time frame: At the beginning of the study.
Ran from Feb 2018 to primary completion in Sep 2019, 18 months.
Of 5,147 non-industry interventional studies with no phase under Motor Activity, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 36. This study's 18 months is close to that.
Counting every sponsor, half of 5,207 studies reached it within 17 months; a quarter within 7 and three quarters within 36.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Sep 2019. You cannot join it, but the record below documents what was studied.
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