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CompletedNCT03408951Updated Aug 21, 2019

Surface ECG Signal Recording for the Implantable Subcutaneous String Defibrillator (ISSD) Detection Algorithm Performance Assessment

An observational study in Tachyarrhythmia and Arrhythmias, Cardiac, sponsored by NewPace Ltd. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-08-21.

Sponsored by NewPace Ltd · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
91
Ages
18 Years and older
Sex
All
01

Study summary

Recorded cutaneous ECG containing arrhythmia events are separately analysed by an expert Electrophysiologist and the ISSD detection algorithm, to allow assessment of the correct detection of tachyarrhythmia events and discrimination of supra-ventricular arrhythmia of the algorithm,m compared to the expert.

Read the detailed description

cutaneous ECG electrodes positioned near the sternum and on the midaxillary line, at the approximate positions of the ISSD sense electrodes, are used to record patients undergoing Defibrillation Threshold (DFT) studies or Electrophysiology (EP) studies of different types. Two separate copies of the recordings undergo parallel and separate analysis: one is sent to an expert Electrophysiologist for determination and classification of arrhythmia events of at least 5 seconds and at least 170 beats per minute. the other is fed to the ISSD detection algorithm, with a low cutoff rate of 170 beats per minute. the results are compared to establish the accuracy of the detection algorithm and the rate of false detection / classification of arrhythmia events.

02

Conditions studied

  • Tachyarrhythmia
  • Arrhythmias, Cardiac
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with high chance of having a cardiac tachyarrhythmia

Inclusion criteria

  • candidate for ICD implantation
  • candidate for an ICD DFT study
  • candidate for an EP study

Exclusion criteria

Exclusion Criteria:

  • age \<18
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
91 participants (actual)
Patient registry
No

Groups and cohorts

  • Interventions (recording)

    Patients requiring Intracardiac defibrillator (ICD) implantation or Defibrillation Test (DFT) or Electrophysiology (EP) study with high probability of supra ventricular tachyarrhythmia.

    Other: Recording

Interventions

  • OtherRecording

    The patient cutaneous ECG is recorded, to later be comparatively analysed by an expert and by the ISSD detection algorithm

05

What researchers measure

Primary outcomes

  1. ISSD algorithm detection rates

    Calculation of the ISSD algorithm detection and classification rates, compared to an EP expert analysis of the ECG traces

    Time frame: through study completion, expected at 15 months

06

Study locations

1 site
  • St Francis Hospital Heart Center
    Roslyn, New York 11576, United States
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03408951
Lead sponsor
NewPace Ltd
Responsible party
Sponsor
First posted
Jan 24, 2018
Start date
Mar 2, 2017
Primary completion
Dec 5, 2018
Completion
Dec 5, 2018
Last update
Aug 21, 2019

Study contacts

Joseph H Levine, M.D
principal investigator · St Francis Hospital Heart Center
David Hoch, M.D
principal investigator · St Francis Hospital Heart Center

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.

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