An observational study in Antibiotic, Anti-Bacterial Agents and Surgical Wound Infection, sponsored by Johannes Gutenberg University Mainz. Completed at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-05-30.
Sponsored by Johannes Gutenberg University Mainz · Observational
This study evaluates antibiotic serum concentrations in correlation with perioperative fluid balance. Patients will be recruited in rectum and esophageal surgery (representative for low blood loss and restrictive fluid management) and in liver surgery (representative for high blood loss and liberal fluid management). The hypothesis is that high blood loss and liberal fluid management dilute antibiotic serum concentrations thereby potentially increasing surgical site infections.
Surgical Patients of the University Medical Center Mainz
Exclusion Criteria:
Sampling of 6 x 8 mL (in sum 48 mL) via the central venous line (established for the surgical procedure) until postoperative day 2
Serum concentration of antibiotic
ug/mL
Time frame: 2 days
Surgical wound infection
Incidence
Time frame: 30 days
Plan to share: No
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This study is completed, as verified in May 2019. You cannot join it, but the record below documents what was studied.
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Johannes Gutenberg University Mainz