A Phase 2/3 interventional study of Sodium bicarbonate supplementation and Placebo treatment in Supplementation and Sport, sponsored by Poznan University of Life Sciences. Completed at 1 site in Poland. Open to participants aged 17 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-01-23.
Sponsored by Poznan University of Life Sciences · Phase 2/3, Interventional, and Treatment
The purpose of this study was to verify the effect of 10-day sodium bicarbonate (NaHCO3) and placebo (PLA) supplementation on physical and specific performance capacity, as well as concentrations of the selected biochemical blood markers in trained combat sports athletes, in a randomised, double-blind, placebo-controlled trial.
Sodium bicarbonate (NaHCO3) was proposed as an ergogenic agent, because it improves high-intensity and resistance exercise performance. Until now the major limitation to NaHCO3 supplementation has been the gastrointestinal (GI) side effects. Therefore, this study aims to examine the effect of chronic, progressive-dose NaHCO3 ingestion on physical capacity and specific performance capacity, and concentrations of the selected biochemical blood markers in trained combat sports athletes, in a randomised, double-blind, placebo-controlled trial.
Exclusion Criteria:
Group taking oral NaHCO3 supplementation in a progressive-dose regimen.
Dietary Supplement: Sodium bicarbonate supplementation
Group taking oral supplementation with placebo (maltodextrin with NaCl) in a similar tablet form prepared by the same producer as NaHCO3 tablets.
Dietary Supplement: Placebo treatment
The experimental procedure for each athlete included a 10-day NaHCO3 supplementation in a progressive-dose regimen in order to reduce the likelihood of gastrointestinal side effects (from 25 to 100 mg ∙ kg-1). NaHCO3 was administered in the form of unmarked disk-shaped tablets (Alkala T, SANUM, Poland). The tablets were ingested with at least 250 mL of water and could be either swallowed or dissolved in the mouth. On training days the supplements were taken in the morning, in the evening and 1.5 hours before training session. On rest days the supplements were taken in the morning, in the afternoon and in the evening.
The experimental procedure for each athlete included a 10-day placebo administration. Placebo was ingested with at least 250 mL of water. On training days the supplements were taken in the morning, in the evening and 1.5 hours before training session. On rest days the supplements were taken in the morning, in the afternoon and in the evening.
Changes in anaerobic capacity after sodium bicarbonate supplementation
The Wingate Anaerobic Test (WAnT)
Time frame: Baseline and after 10 days
Changes in specific performance capacity after sodium bicarbonate supplementation
The wrestler's special endurance test - projective test with dummy (DT)
Time frame: Baseline and after 10 days
Changes of lactate and pyruvate concentration in blood after sodium bicarbonate supplementation
Lactate \[mmol/L\] and pyruvate \[mmol/L\] concentration analysis
Time frame: Baseline and after 10 days
Changes of creatine kinase and lactate dehydrogenase activity in blood after sodium bicarbonate supplementation
Creatine kinase \[U/L\] and lactate dehydrogenase \[U/L\] activity analysis
Time frame: Baseline and after 10 days
Changes in blood glucose and hemoglobin concentration after sodium bicarbonate supplementation
Hemoglobin (Hb) \[g/dl\] and glucose \[g/dl\] concentration analysis
Time frame: Baseline and after 10 days
Changes in blood hematocrit levels after sodium bicarbonate supplementation
Hematocrit (HCT) \[%\] level analysis
Time frame: Baseline and after 10 days
Changes of red and white blood cell concentration in blood after sodium bicarbonate supplementation
Red blood cells (RBC) \[mln/mm³\] and white blood cells (WBC) \[mln/mm³\] concentration analysis
Time frame: Baseline and after 10 days
Changes in polyphenols and albumin concentration
Polyphenols \[g/L\] and and albumin \[g/L\] concentration analysis
Time frame: Baseline and after 10 days
Changes in FRAP concentration
FRAP \[µmol/L\] concentration analysis
Time frame: Baseline and after 10 days
Plan to share: Undecided — Shared data will be exclusively related to the level recorded indicators (anaerobic capacity and specific performance capacity indicators, levels of biochemical markers, body composition), without personal data. The data obtained will be attached to scientific publications, depending on the requirements of the journal.
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Poznan University of Life Sciences