CClinicalTrials.gg
Status unknownNCT03404141Updated May 5, 2021

Stress Reduction Therapy for Pregnant Women

An interventional study of Parent craft and Cognitive-Behavioral Therapy in Prenatal Stress, sponsored by Universidad de Granada. Status unknown at 1 site in Spain. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-05-05.

Sponsored by Universidad de Granada · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Apr 2021), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
18 Years and older
Sex
Female
01

Study summary

Prenatal stress is associated with negative outcomes such as postpartum depression, prematurity or neurodevelopmental delays.

The aim of this study is to implement a psychological therapy to reduce stress during pregnancy.

Read the detailed description

Objective: To assess whether the group of pregnant women have lower levels of stress after attending the psychological therapy than the group attending parent craft classes.

The cognitive-behavioural therapy to reduce stress will be held in 10 sessions (1 per week) as follows:

First session: General information about pregnancy. Pregnant women will describe what can they do to reduce stress levels.

Second session: Breathing techniques and talk about how last week went. Third session: Muscle relaxation and guided imagination techniques Fourth session: Cognitive restructuring. Being able to detect thoughts and feelings Fifth session: Detect cognitive distortions Sixth session: Cognitive restructuring Seventh session: Time management Eighth session: Problems solving Ninth session: Assertively and social skills Tenth session: How to ask for help when needed and learning to say "No".

02

Conditions studied

  • Prenatal Stress

Keywords

  • Stress
  • pregnancy
  • psychological therapy
  • cortisol
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
Female
Accepts healthy volunteers
Yes

Inclusion criteria

  • Low risk Pregnant women
  • Gestational age between 10-27 weeks
  • Proficiency in the Spanish language

Exclusion criteria

Exclusion Criteria:

  • Corticoids treatment
  • Gestational Diabetes
  • Psychological diagnosed
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
40 participants (estimated)

Study arms

  • Experimental
    Experimental group

    The intervention administered to the experimental group will be a cognitive-behavior therapy applied by two specifically trained psychologists. Due to COVID-19 pandemic, this group will be implemented online using a videocall online platform (from April 2019 to the end of mobility restrictions).

    Behavioral: Cognitive-Behavioral Therapy

  • Active comparator
    Control group

    The intervention administered to the control group will consist on a regular parent craft classes offered by the community midwife Due to COVID-19 pandemic, this group will be implemented online using a videocall online platform (from April 2019 to the end of mobility restrictions).

    Other: Parent craft

Interventions

  • OtherParent craft

    Midwife-guided classes for pregnant women about pregnancy and childbirth

  • BehavioralCognitive-Behavioral Therapy

    Cognitive-Behavioral Therapy to reduce stress levels among pregnant women

05

What researchers measure

Primary outcomes

  1. Change in hair cortisol levels

    Change in hair cortisol levels at different time points

    Time frame: Baseline, and 3 months

Secondary outcomes

  1. Change in Perceived Stress Scale (PSS)

    The PSS provides information on the perception of general stress during the preceding month. It consists on 14 items scores on a 5-point Likert scale (0 = never, 1 = almost never, 2 = once in a while, 3 = often, 4 = very often). Scores range from 0-56 (higher scores represent higher levels of stress)

    Time frame: Baseline, and 3 months

  2. Change in Prenatal Distress Questionnaire (PDQ)

    It is a 12-item instrument scored on a 5-point Likert scale from 0 (none at all) to 4 (extremely) to assess specific worries and concerns pregnant women experience regarding medical problems, physical symptoms, body changes, labor, childbirth, relationships, and the baby's health. Scores range from 0-48 (higher scores represent higher levels of pregnancy specific-stress)

    Time frame: Baseline, and 3 months

  3. Change in Symptoms Checklist 90 Revised (SCL-90-R)

    This is a 90-item scale scored using a 5-point Likert scale from 0 (never) to 4 (extremely). This instrument is used to assess 9 dimensions: Somatization, Obsession-compulsion, Interpersonal sensitivity, Depression, Anxiety, Hostility, Phobic anxiety, Paranoid ideation, and Psychoticism. The scale also has 7 extra items distributed among 3 global indexes of distress: the GSI, which measures overall psychological distress; the PSDI, which is used to measure the intensity of symptoms; and Positive Symptom Total, used to measure the number of self-reported symptoms. Using the author´s instructions, the scores are transformed to percentiles (0-100). Percentiles ≥ 70 represent clinical symptoms in any of the subscale of this instrument.

    Time frame: Baseline, and 3 months

  4. Change in Connor-Davidson Resilience Scale (CD-RISC)

    It consists of 25 items evaluated on a 5-point Likert scale ranging from 0-4: not true at all (0), rarely true (1), sometimes true (2), often true (3), and true nearly all of the time (4) - these ratings result in a number between 0-100, and higher scores indicate higher resilience.

    Time frame: Baseline, and 3 months

Other outcomes

  1. Infant neurodevelopment

    Infant neurodevelopment at 6 months of age

    Time frame: 6 months of age

06

Study locations

1 of 1 sites recruiting
  • Granada
    Churriana de la vega, Granada 18194, Spain
    Recruiting
07

References and documents

Publications

  • Romero-Gonzalez B, Puertas-Gonzalez JA, Strivens-Vilchez H, Gonzalez-Perez R, Peralta-Ramirez MI. Effects of cognitive-behavioural therapy for stress management on stress and hair cortisol levels in pregnant women: A randomised controlled trial. J Psychosom Res. 2020 Aug;135:110162. doi: 10.1016/j.jpsychores.2020.110162. Epub 2020 May 26. PubMed 32485622 ↗
08

Registry details

Key details

Study ID
NCT03404141
Lead sponsor
Universidad de Granada
Responsible party
Borja Romero-Gonzalez (PhD, Universidad de Granada) — Principal investigator
First posted
Jan 19, 2018
Start date
Jun 1, 2018
Primary completion
Jun 2021 (estimated)
Completion
Dec 2021 (estimated)
Last update
May 5, 2021

Study contacts

Borja Romero
Contact
borjaromero@ugr.es
651048189
Borja Romero
principal investigator · Universidad de Granada

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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