An interventional study of Dexmedetomidine and Midazolam in Hypercatabolism and Sedative, Hypnotic, or Anxiolytic Use Disorders, sponsored by Chinese Medical Association. Status unknown at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2018-03-29.
Sponsored by Chinese Medical Association · Not applicable, Interventional, and Treatment
To investigate the effects of different sedation protocols on skeletal muscle metabolism in mechanical ventilated patients in ICU. Mechanical ventilated patients who are anticipated to stay in ICU for more than 5 days are enrolled and randomly assigned to the following three groups, interventional group(dexmedetomidine), control group(midazolam) and no sedation group. Serum, CT scan of intercostal muscles, ultrasound evaluation of quadriceps femoris are obtained.
Exclusion Criteria
Dexmedetomidine consistent infusion as sedative.
Drug: Dexmedetomidine
Midazolam consistent infusion as sedative.
Drug: Midazolam
consistent infusion at a loading dose of 0.15ug/kg/h, increased by 0.15ug/kg/h, with a maximum dose of 1.5ug/kg/h.
consistent infusion at a loading dose of 1mg/h, increased by 1mg/h, with a maximum dose of 10mg/h.
acute muscle wasting
measured by 3-MH release in serum
Time frame: From date of randomization to extubation,up to 7 days
28-day mortality
death rate within 28 days after mechanical ventilation
Time frame: From date of randomization to date of death from any cause,up to 28 days
length of ICU stay
time from enrollment to discharge or die
Time frame: From date of randomization to date of to discharge or death,up to 28 days
Plan to share: No — Individual participant data is not available to other researchers after publication.
No publications or documents are linked to this record.
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Chinese Medical Association