An interventional study of blood test and electromyogram and walk test in Poliomyelitis Sequelae, sponsored by University Hospital, Montpellier. Completed at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-12-14.
Sponsored by University Hospital, Montpellier · Not applicable, Interventional, and Other
Many patients with polio sequelae have persistent and progressive worsening more than 15 years after the initial damage, with loss of muscle strength, asthenia and musculoskeletal pain. In these patients, there is a denervation process associated with insufficient reinnervation. The frequency of this syndrome post-polio (SPP) is of the order of 20 to 60% according to the studies. In the literature, several studies have advanced the hypothesis of immune dysregulation to this late degradation, with greater expression of pro-inflammatory cytokines, and abnormal phenotypic expression of T cells in the bloodstream. In this context, the use of immunomodulatory immunoglobulin IV treatment was studied several times, with no significant result on pain, fatigue and muscle strength scores. In the absence of significant efficacy of immunoglobulin treatment, the objective of this study is therefore to define the immunological profile of patients with post-polio syndrome, compared with control subjects, in order to support the pathophysiology of this syndrome. to study the possible presence of an inflammatory syndrome associated with this syndrome. On the other hand, depending on the results found, referral to targeted therapies could be considered.
Subjects with Post-polio Syndrome :
Controlled subjects :
Exclusion Criteria:
during the visit, nurse will make a blood test for biological and immunological analysis, electromyogram and walk test
Biological: blood test · Other: electromyogram and walk test
during the visit, nurse will make a blood test for biological and immunological analysis
Biological: blood test
during the visit, nurse will make a blood test for biological and immunological analysis
during the visit, measuring the amount of functional motor units at the muscular level and the distance traveled during a 2 minute walk
cytokines blood concentrations
Time frame: blood sample during inclusion visit
lymphocytes blood concentrations
Time frame: blood sample during inclusion visit
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University Hospital, Montpellier