A Phase 1 interventional study of Misoprostol + syntocinon and using extra uterotonic drugs when needed ; methergine and Syntocinon and using extra uterotonic drugs when needed ; methergine carboprost in Cesarean Section, sponsored by Aljazeera Hospital. Completed at 1 site in Egypt. Open to female participants aged 18 Years to 42 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-11-16.
Sponsored by Aljazeera Hospital · Phase 1, Interventional, and Prevention
Several treatment strategies are emplemented to prevent post delivery hemorage and decreasing maternal morbidity and mortality .
Many approved drugs are used in prophylaxis against postpartum hemorage from these medications are the (syntocinon combined with methergine ) that are known as active management of labour drugs .
Moreover there is misotac , that also guards against postpartum hemorage .
All these medications act in a different way to cause uterine contraction post delivery to prevent uterine atony .
-Here we are comparing the additive value of misotac intrauterine to syntocinon and methergine in comparison to the usually used syntocinon plus methergine .
Inclusion Criteria:
All patients included in this research were aged 18-42 years, pregnant 37 weeks till 42 weeks
Exclusion Criteria:
Exclusion Criteria:
-Procedure : Giving misoprostol plus syntocinon during CS this group in which prevention of uterine atony is made by intrauterine misoprostol plus the usual syntocinon and using extra uterotonic drugs when needed ; methergine , carboprost
Drug: Misoprostol + syntocinon and using extra uterotonic drugs when needed ; methergine
* Procedure: Giving syntocinon during cesarean section * this group in which prevention of uterine atony is made by the usual active management of labour syntocinon and using extra uterotonic drugs when needed ; methergine , carboprost
Drug: Syntocinon and using extra uterotonic drugs when needed ; methergine carboprost
medical prophylaxis against postpartum atony and postpartum hemorage by giving misoprostol plus syntocinon and using extra uterotonic drugs when needed ; methergine, carboprost
Also known as: DrugsMisoprostol plus syntocinon and using extra uterotonic drugs when needed ; methergine , carboprost
medical prophylaxis against postpartum atony and postpartum hemorage by giving syntocinon and using extra uterotonic drugs when needed ; methergine, carboprost
Also known as: drugs ( syntocinon and using extra uterotonic drugs when needed ; methergine, carboprost
The number of participants who passed cesarean section without postpartum hemorage
Time frame: within 2 days post CS
Plan to share: No
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Aljazeera Hospital