An interventional study of Fluid challenge in Liver Transplantation, sponsored by Kasr El Aini Hospital. Status unknown at 2 sites in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-03-29.
Sponsored by Kasr El Aini Hospital · Not applicable, Interventional, and Diagnostic
finding surrogate to co to trace the effect of preload challenge would make the test more applicable without the need of advanced hemodynamic monitors,suggested that co2 gap can be used to detect FR after mini fluid challenge and fluid bolts .
use of carbon dioxide gap and arterio venous oxygen content to trace the effect of preload challenge by giving via a specific venous line , first 150 ml is infused over one minute, after stroke volume at one minute measure the remaining 350 ml is infused over 14 minutes at constant rate , the fluid challenge performed with albumin 5% , fluid responsiveness is an increase in stroke volume by 15% after infusion of 500ml albumin 5%.
Objectives is to investigate the ability of VA-co2 gap and gap/ ratio to predict the hemodynamic response to mini fluid challenge, and to compare the validity of VA-co2 gap and gap/ratio with svo2 for prediction of fluid responsiveness.
Kasr El Aini Hospital is the lead sponsor of 283 studies on the registry; 33 are open to participants now.
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Exclusion Criteria:
The patients will receive fluid bolus and observe changes in co2 gap and gap/ ratio in them.
Diagnostic Test: Fluid challenge
Fluid challenge and measure change in co2 gap
co2gap
Difference between arterial and venous co2 gap
Time frame: 30 minuets after fluid bolus
Stroke volume
Stroke volume assessed by cardiometry
Time frame: Baseline 30 minutes after Icu admission, 1 minutes after mini fluid challenge , 30 minutes after fluid bolus
Plan to share: No
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Started Jun 2017 (actual). Primary completion is estimated for May 2018, 11 months after the start.
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This study is status unknown, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.
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