An Early Phase 1 interventional study of [C-11] and NOP-1A in Cocaine Use Disorder, sponsored by University of Pittsburgh. Completed at 1 site in United States. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-08-05.
Sponsored by University of Pittsburgh · Early Phase 1, Interventional, and Basic science
The goal of this study is to compared [C-11]NOP-1A binding in recently abstinent cocaine use disorders and controls.
This will allow for understanding brain stress and anti-stress mechanisms that underlie abuse of cocaine in humans.
University of Pittsburgh is the lead sponsor of 1,419 studies on the registry; 168 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 4 (44%) have results posted.
Counted across the registry records on this site, refreshed daily.
[A]Cocaine use disorders
Inclusion criteria:
Major exclusion criteria:
[B] Healthy controls
Inclusion criteria:
Major exclusion criteria
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
PET scan
Radiation: [C-11] · Drug: NOP-1A
PET scan
Radiation: [C-11] · Drug: NOP-1A
Radiolabel
Tracer
[C-11]NOP-1A VT
VT-volume of distribution expressed relative to total plasma
Time frame: Baseline
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Aug 2019. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: NOP-1A