An Early Phase 1 interventional study of [18F]F13640 and [18F]F13640 in Neurological Pathology and Healthy Subjects, sponsored by Hospices Civils de Lyon. Completed at 1 site in France. Open to male participants aged 20 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-12.
Sponsored by Hospices Civils de Lyon · Early Phase 1, Interventional, and Basic science
This clinical assay is designed to validate that [18F]F13640 as a radiotracer of 5-HT1A functional receptors. A first group of healthy subjects underwent a PET scan with arterial blood sampling to determine the kinetic model of the tracer. A second group of healthy subjects underwent a classical test-retest study (i.e two distant PET scans) to determine the reproducibility of measures.
Exclusion Criteria:
Subjects with neurologic or psychiatric disease including all substance addictions
Each subject underwent a 90 min acquisition PET scan with concomitant arterial blood sampling
Drug: [18F]F13640
Each subject underwent 2 PET scans distant from 1 to 3 weeks
Drug: [18F]F13640
Radiotracer injection and PET scan acquisition of 90 min: \*150 Mbq + 1 MBq/Kg of \[18F\]F13640 at t=0 min Arterial Blood Sampling during the 90min acquisition
2 Radiotracer injections and PET scan acquisition of 90 min distant from 1 to 3 weeks: For each exam: 150 MBq + 1 MBq/kg of \[18F\]F13640 at t=0 min
Binding potentials
Binding potentials are calculated using compartimental modelling techniques.
Time frame: 180 minutes
This study is completed, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.
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Hospices Civils de Lyon