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CompletedNCT03339440Updated Nov 4, 2021

A Trial of an Integrated Clinic-community Intervention in Children and Adolescents With Obesity (Hearts and Parks)

An interventional study of Hearts & Parks in Childhood Obesity, Pediatric Obesity and Quality of Life, sponsored by Duke University. Completed at 3 sites in United States. Open to participants aged 5 Years to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-11-04.

Sponsored by Duke University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
327
Allocation
Randomized
Ages
5 Years to 18 Years
Sex
All
01

Study summary

The investigators propose a randomized controlled effectiveness trial to evaluate the integrated clinic-community model of child obesity treatment as compared with routine primary care.

Read the detailed description

The purpose of this study is to evaluate how different types of physical activity and nutrition education and support (in addition to normal clinical care) affect children's health. The investigators will be looking at changes in child BMI, physical activity, nutrition, and overall health. The investigators also hope to better understand biological differences in metabolism and the microbiome (the bacteria that grows normally on and in the body) in children with high BMI who are making lifestyle changes.

02

Conditions studied

  • Childhood Obesity
  • Pediatric Obesity
  • Quality of Life
  • Cardiovascular Risk Factor
03

Who can participate

Ages eligible
5 Years to 18 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Child age 5-18 years
  • Child body mass index ≥ 95th %ile
  • Parent can speak and read in English or Spanish
  • Parent ownership of a device that is able to receive and send text messages

Exclusion criteria

Exclusion Criteria:

  • Live farther than a 20-mile radius from the Healthy and Fit program site
  • Endogenous or genetic cause of obesity
  • Taking a medication that causes weight gain
  • Participation in a pediatric weight management program within 12 months
  • Parent or child significant health problem that would limit participation
  • Enrollment is above the max weekly enrollment of 60 participants/week)
  • Reported or planned pregnancy

Opt-out Criteria

  • Primary care physician opts patient out of study for reasons including: severe obesity, urgent co-morbidities, parental unwillingness to be contacted by a research assistant, or at physician clinical judgment.
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
327 participants (actual)

Study arms

  • Experimental
    Intervention Group

    Patients in this group will be receiving the Hearts and Parks intervention.

    Behavioral: Hearts & Parks

  • No intervention
    Control Group

    Patients in this group will continue receiving standard of care.

Interventions

  • BehavioralHearts & Parks

    The Hearts \& Parks intervention will be looking to evaluate how different types of physical activity and nutrition education and support (in addition to normal clinical care) through attendance and participation in the Duke Healthy Lifestyles/Bull City Fit clinic/community program, affect children's health. The investigators will be looking at changes in BMI, physical activity, nutrition and overall health.

05

What researchers measure

Primary outcomes

  1. Change in z-BMI

    Time frame: Baseline, 6 months

  2. Change in heart rate

    Time frame: baseline, 12 months

  3. Number of subjects enrolled versus number of subjects who meet min. participation criteria

    As measured by enrollment logs

    Time frame: 12 months

  4. Change in molecular pathways dysregulated in pediatric obesity

    Stool and blood samples

    Time frame: Baseline, 6 months

  5. Physical activity

    child physical activity; objectively tracked with fitness tracker

    Time frame: Up to 12 months

  6. Change in child fitness

    3 minute bench stepping test

    Time frame: baseline, 3 months, 12 months

  7. Change in Child Quality of Life

    Composite score of Sizing Me Up Questionnaires

    Time frame: baseline, 3 months, 12 months

  8. Change in Body Appreciation

    Body appreciation scale 13-item questionnaire (1. Never, 2. Seldom, 3. Sometimes, 4. Often, 5. Always)

    Time frame: baseline, 3 months, 12 months

  9. Change in FLASHE Food and Activity Screener Scores

    Questionnaire about child and parent nutrition and activity habits

    Time frame: Baseline, 6 months, 12 months

  10. Change in fasting lipid profile

    Time frame: Baseline, 6 months, 12 months

  11. Change in fasting glucose

    Time frame: Baseline, 6 months, 12 months

  12. Change in alanine aminotransferase (A1)

    Time frame: Baseline, 6 months, 12 months

  13. Change in child quality of life (2)

    PROMIS Questionnaire (not composite score)

    Time frame: baseline, 3 months, 12 months

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Study locations

3 sites
  • Duke Children's Primary Care Roxboro Street
    Durham, North Carolina 27704, United States
  • Durham Pediatrics at North Duke Street
    Durham, North Carolina 27704, United States
  • Regional Pediatrics - North Durham
    Durham, North Carolina 27704, United States
07

References and documents

Publications

  • Neshteruk CD, Zizzi A, Suarez L, Erickson E, Kraus WE, Li JS, Skinner AC, Story M, Zucker N, Armstrong SC. Weight-Related Behaviors of Children with Obesity during the COVID-19 Pandemic. Child Obes. 2021 Sep;17(6):371-378. doi: 10.1089/chi.2021.0038. Epub 2021 Apr 26. PubMed 33902326 ↗
  • Armstrong SC, Windom M, Bihlmeyer NA, Li JS, Shah SH, Story M, Zucker N, Kraus WE, Pagidipati N, Peterson E, Wong C, Wiedemeier M, Sibley L, Berchuck SI, Merrill P, Zizzi A, Sarria C, Dressman HK, Rawls JF, Skinner AC. Rationale and design of "Hearts & Parks": study protocol for a pragmatic randomized clinical trial of an integrated clinic-community intervention to treat pediatric obesity. BMC Pediatr. 2020 Jun 26;20(1):308. doi: 10.1186/s12887-020-02190-x. PubMed 32590958 ↗

Individual participant data

Plan to share: No

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Registry details

Key details

Study ID
NCT03339440
Lead sponsor
Duke University
Responsible party
Sponsor
First posted
Nov 13, 2017
Start date
Jan 10, 2018
Primary completion
Jun 30, 2021
Completion
Jun 30, 2021
Last update
Nov 4, 2021

Study contacts

Sarah Armstrong, MD
principal investigator · Duke University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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