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CompletedNCT03319264SASPARUpdated Dec 19, 2025

Sarcopenia in Axial and Peripheral Spondyloarthropathies

An interventional study of Dynamometry exam and Walking test in Spondylarthropathy and Sarcopenia, sponsored by Hospices Civils de Lyon. Completed at 1 site in France. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-12-19.

Sponsored by Hospices Civils de Lyon · Not applicable, Interventional, and Screening

Phase
Not applicable
Study type
Interventional
Enrollment
106
Allocation
Not applicable
Ages
18 Years to 80 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-13

Among 12 studies in Spondylarthropathies with a site in France — 2 open to participants now, 2 under way, none of them phase 3. Spondylarthropathies · France.

Started
2017
the only one that year
No phase
4 of 12
2 open now
Registered
9th of 12
by date
Lead sponsor
1 of 12
Hospices Civils de Lyon

Among the 12 studies in Spondylarthropathies with a site in France, this one is the only one that started in 2017, is one of 4 with no phase, and was the 9th registered.

Spondylarthropathies

68 studies on the registry are indexed under Spondylarthropathies; 10 are open to participants now.

Browse Spondylarthropathies studies →

Open to participants now

2 of the 12 studies in Spondylarthropathies with a site in France are open now. Recruiting first, the newest first:

All 2 open studies →

A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →

Who these studies take

Of the 6 Spondylarthropathies studies recruiting now, 2 set no upper age limit and 3 stop at 75 or younger; 1 takes children under 18; 1 takes healthy volunteers.

This study: 18 Years to 80 Years · all sexes · no healthy volunteers.

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02

Study summary

Spondylarthropathies (SpA) are among the most common chronic inflammatory rheumatisms in adults, responsible for a muscular loss or sarcopenia which can be very disabling, not much documented in the literature, and not yet studied in France. In addition, sarcopenia is associated with decreased physical activity and increased risk of falls and fractures. A better characterization of the determinants of this muscular loss will allow to better detect and take care of it.

The aim is to conduct the first French study on the prevalence and severity of sarcopenia in patients with spondyloarthropathies and to study the variables that may be associated with it. Finally, we propose to evaluate obesity related to sarcopenia in these patients and compare them to cases matched for age and sex (from OFELY / STRAMBO cohorts, Lyon, FRANCE).

This is a prospective interventional and monocentric study with minimal risks and constraints: patients will be included for one day for an evaluation of their sarcopenia by measuring their muscle strength, physical performance and body composition and recording of their socio-demographic and disease characteristics.

03

Conditions studied

  • Spondylarthropathy
  • Sarcopenia

Keywords

  • Spondylarthropathy
  • Sarcopenia
  • lean mass
  • fat mass
04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Men and women, 18 to 80 years old
  • Hospitalized or attending the rheumatology department for spondyloarthopathy.

Exclusion criteria

Exclusion Criteria:

  • no signed consent
  • Immobilization for a period of more than 15 days during the last 3 months
  • pregnant or breastfeeding woman
  • Not affiliated to the national healthcare insurance
  • difficulty in understanding French
  • psychiatric disorder
05

Study design

Phase
Not applicable
Primary purpose
Screening
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
106 participants (actual)

Study arms

  • Experimental
    Patients with SpA

    Patients included in this single group study will have 3 interventions to assess the severity of muscle loss : * dynamometry exam * walking test * Dual-energy X-ray Absorptiometry (DXA) measurement Quality of life will be assessed with Sarcopenia \& Quality of Life (SARQOL) questionnaire. Patients will also fill a Life habits Questionnaire.

    Other: Dynamometry exam · Other: Walking test · Radiation: DXA measurement · Other: SARQOL questionnaire · Behavioral: Life habits Questionnaire

Interventions

  • OtherDynamometry exam

    Prehension strength of the main hand will be assessed thanks to dynamometry, in order to evaluate patient's muscular strength

  • OtherWalking test

    A 4 metres walking test will be performed to assess patient's walking speed

  • RadiationDXA measurement

    DXA measurement will be performed to assess patient's body composition

  • OtherSARQOL questionnaire

    Patient's quality of life will be assessed thanks to the SARQOL questionnaire

  • BehavioralLife habits Questionnaire

    Life habits Questionnaire

06

What researchers measure

Primary outcomes

  1. Muscular strength

    Muscular strength is the first outcome to evaluate sarcopenia

    Time frame: At day 1

  2. Walking speed

    Walking speed is a physical performance outcome, that is the second outcome to evaluate sarcopenia

    Time frame: At day 1

  3. Muscular mass

    Muscular mass is the third outcome to evaluate sarcopenia and will be assessed using DXA

    Time frame: Up to 4 month after inclusion

Secondary outcomes

  1. Alcohol consumption

    Time frame: At day 1

  2. Tobacco consumption

    Time frame: At day 1

  3. Time of sport practice per month

    Number of hours of sport practice per month is the first outcome to evaluate patient's global physical activity.

    Time frame: At day 1

  4. Physical activity rate in work

    Physical activity rate in work can be light, medium, high or not applicable if the patient does not work ; it is the second outcome to evaluate patient's physical global activity.

    Time frame: At day 1

  5. Average walking time in a week

    Average walking time in a week is the third outcome to evaluate patient's physical global activity.

    Time frame: At day 1

  6. Score at the SARQOL questionnaire

    Quality of life will be assessed thanks to the SARQOL questionnaire (score between 0 and 100)

    Time frame: At day 1

07

Study locations

1 site
  • Service de Rhumatologie - Hôpital Edouard Herriot
    Lyon, 69003, France
08

References and documents

Publications

  • Merle B, Cottard M, Sornay-Rendu E, Szulc P, Chapurlat R. Spondyloarthritis and Sarcopenia: Prevalence of Probable Sarcopenia and its Impact on Disease Burden: The Saspar Study. Calcif Tissue Int. 2023 Jun;112(6):647-655. doi: 10.1007/s00223-023-01074-3. Epub 2023 Mar 21. PubMed 36944706 ↗

Individual participant data

Plan to share: No

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Nov 2017 to primary completion in Jul 2018, 8 months.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 18, 2017
First posted
Oct 24, 2017
StartActual
Nov 2, 2017
Primary completionActual
Jul 4, 2018
CompletionActual
Jul 4, 2018
Last update
Dec 19, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Dec 19, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03319264
Responsible party
Sponsor
First posted
Oct 24, 2017
Start date
Nov 2, 2017
Primary completion
Jul 4, 2018
Completion
Jul 4, 2018
Last update
Dec 19, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.

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