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CompletedNCT03299348Updated Jun 19, 2025

AgingPLUS: Promoting Physical Activity in Adults

An interventional study of AgingPLUS and Active Control Group in Physical Activity, sponsored by Colorado State University. Completed at 1 site in United States. Open to participants aged 45 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-06-19.

Sponsored by Colorado State University · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
402
Allocation
Randomized
Ages
45 Years to 75 Years
Sex
All
01

Study summary

This study examines the efficacy of a psycho-educational intervention program, AgingPLUS, with regard to increasing middle-aged and older adults' engagement in physical activity.

Read the detailed description

AgingPLUS is a multi-component intervention program that addresses negative views of aging (NVOA), low internal control beliefs, and deficient goal planning as a risk cluster that keeps adults from engaging in health-promoting behavior. The program focuses on engagement in physical activity (PA) as the health behavior of choice. Engagement in PA is widely recognized as the best non-pharmacological, non-invasive, and cost-effective method of health promotion. Yet, only 20% of the adult population meets the recommended PA guidelines. This suggests that messages about the benefits of PA alone are not effective. Rather, it is essential to address the social-cognitive and motiva-tional mechanisms that prevent adults from adopting and maintaining a regular PA regimen. NVOA, low internal control beliefs, and deficient goal planning represent such a cluster of social-cognitive and motivational mechanisms.

Given this background, the specific aims and hypotheses of the proposed research are:

Aim 1: To conduct a randomized controlled trial examining the efficacy of the AgingPLUS program.

Aim 2: To test a conceptual model of the mechanisms underlying the intervention effects.

Aim 3: To conduct a 6-month follow-up to examine the longer-term effects of AgingPLUS.

Upon completion of this project, we expect to have successfully established evidence for the efficacy of the AgingPLUS program (Stage II of the NIH Stage Mode). The long-term goal is to develop AgingPLUS into a full-fledged evidence-based program that can be implemented in community settings (e.g., senior centers), and can serve as a fairly brief and cost-effective public health tool to promote healthy and successful aging.

02

Conditions studied

  • Physical Activity

Keywords

  • Psychological Mechanisms
  • Social-Cognitive Mechanisms
03

Who can participate

Ages eligible
45 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Adults who engage in less than 60 minutes of PA per week and who intend starting a physical exercise program.
  • English speaking.
  • Willingness to be randomized to one of two programs.
  • Willingness to take part in the physical fitness tests and wear an accelerometer.
  • Willingness to commit to follow-up testing (i.e., not moving out of the area during the study period).
  • Physician clearance to take part in a submaximal exercise test and to begin an exercise program.

Exclusion criteria

Exclusion Criteria:

  • Signs of cognitive decline (defined as more than 4 errors on the Short Portable Mental Status Questionnaire).
  • Severe vision and/or hearing loss (obtained by self-report).
  • Serious problems with mobility.
  • A history of neurological, mental, or substance abuse disorders.
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Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Care provider, Outcomes assessor)
Enrollment
402 participants (actual)

Study arms

  • Experimental
    Active Treatment Group

    This group will get the AgingPLUS intervention program which addresses negative views on aging, low internal control beliefs, and deficient goal planning skills.

    Behavioral: AgingPLUS

  • Placebo comparator
    Active Control Group

    This group will get a generic health education program, called the "10 Keys to Healthy Aging". The control program will control for the effect of social contact and will not address the intervention targets of the active treatment group. The health education program will only provide information related to some of the most important health conditions, such as cardiovascular disease, cancer, type 2 diabetes, and clinical depression, and how these conditions can be managed.

    Behavioral: Active Control Group

Interventions

  • BehavioralAgingPLUS

    The program consists of 2-hour meetings for a total of 4 weeks (total of 8 hours) and discusses (a) how negative views on aging and negative age stereotypes undermine adults' health-promoting behaviors; (b) how adults can take control of their own aging; and (c) how personal goals can be achieved through more effective goal planning and action plans.

  • BehavioralActive Control Group

    The program consists of 2-hour meetings for a total of 4 weeks (total of 8 hours) and discusses (a) four major health conditions that affect the lives of many middle-aged and older adults (e.g., cardiovascular disease, cancer, type 2 diabetes; clinical depression); and (b) how these conditions can be managed successfully.

05

What researchers measure

Primary outcomes

  1. Increased physical activity

    We expect that participants significantly increase their engagement in physical activity as assessed by an accelerometer.

    Time frame: This effect should be observable (1) at the Week-4 post-test, (2) the Week-8 post-test, and (3) the 6-Month post-test.

06

Study locations

1 site
  • Colorado State University
    Fort Collins, Colorado 80523-1570, United States
07

References and documents

Publications

  • Brothers A, Diehl M. Feasibility and Efficacy of the AgingPlus Program: Changing Views on Aging to Increase Physical Activity. J Aging Phys Act. 2017 Jul;25(3):402-411. doi: 10.1123/japa.2016-0039. Epub 2016 Dec 5. PubMed 27918687 ↗
  • Diehl M, Nehrkorn-Bailey A, Thompson K, Rodriguez D, Li K, Rebok GW, Roth DL, Chung SE, Bland C, Feltner S, Forsyth G, Hulett N, Klein B, Mars P, Martinez K, Mast S, Monasterio R, Moore K, Schoenberg H, Thomson E, Tseng HY. The AgingPLUS trial: Design of a randomized controlled trial to increase physical activity in middle-aged and older adults. Contemp Clin Trials. 2020 Sep;96:106105. doi: 10.1016/j.cct.2020.106105. Epub 2020 Aug 11. PubMed 32791322 ↗
  • Nehrkorn-Bailey AM, Rodriguez D, Forsyth G, Braun B, Burke K, Diehl M. Change in Views of Aging, Physical Activity, and Physical Health Over 8 Weeks: Results From a Randomized Study. J Aging Phys Act. 2023 Jan 28;31(4):666-678. doi: 10.1123/japa.2022-0133. Print 2023 Aug 1. PubMed 36708712 ↗

Study documents

  • Informed consent form · Sep 9, 2019

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: No

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Registry details

Key details

Study ID
NCT03299348
Lead sponsor
Colorado State University
Collaborators
Johns Hopkins University, National Institute on Aging (NIA)
Responsible party
Manfred Diehl, PhD (Professor, Colorado State University) — Principal investigator
First posted
Oct 3, 2017
Start date
May 1, 2018
Primary completion
May 31, 2023
Completion
May 31, 2023
Last update
Jun 19, 2025

Study contacts

Manfred K. Diehl, PhD
principal investigator · Colorado State University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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