An interventional study of Resistance training and Aerobic interval training in Obesity, sponsored by Southern Illinois University Edwardsville. Terminated at 1 site in United States. Open to female participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-10-04.
Sponsored by Southern Illinois University Edwardsville · Not applicable, Interventional, and Treatment
The overall goal of this project is to study the effects of exercise energy expenditure matched vigorous dynamic resistance training and aerobic training on cardiac fat, and its relationship to cardiac function and geometry using cardiac Magnetic Resonance Imaging.
Exercise-induced weight-loss is one of the most common strategies for reducing excess fat in overweight and obese individuals. Although vigorous intensity may be more favorable promoting positive cardiac adaptations compared to low-moderate intensity, evidence of the positive effects of different exercise modes needs to be explored to allow for realistic comparisons with other strategies. Research using cardiac Magnetic Resonance Imaging that compares the effects of different modes of exercise - matched by exercise energy expenditure - on epicardial adipose tissue and paracardial adipose tissue, and how these interventions modify cardiac function and geometry have not been previously explored in obesity.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
This study's enrollment of 18 is below the median of 67 across 9,006 interventional studies indexed under Obesity.
Browse Obesity studies →Southern Illinois University Edwardsville is the lead sponsor of 6 studies on the registry; none are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Resistance training will consist of a supervised circuit training 3 sessions/week for approximately 45-50 min/session. The circuit will include 7 strength exercises engaging the major muscle groups (leg press, rows, back squats, weighted crunches, deadlifts, bench press, and squat jumps with weights). The participants will perform 3 sets of 10 repetitions with resting periods of 30 seconds between exercises, and 2 minutes between sets. The overall OMNI-Resistance Exercise Scale per set will range between 8-10. Heart rate and exercise energy expenditure during the workout will be monitored. The load will be changed depending on the participants' perception when needed. In addition, the intensity will be monitored assessing Lactate concentrations at baseline and at the end of each session. Circuit will be repeated until meeting the targeted exercise energy expenditure of 450-500 kcal/session.
Other: Resistance training
Aerobic interval will consist of a supervised aerobic interval training sessions 3 times/week. Duration will range between 45-50 min/session depending on the exercise energy expenditure. Each interval will have a total duration of 5 min, and it will be divided into 2 periods. The first period will consist of 3 minutes of high-intensity activity, and the second period the intensity will be reduced for 2 minutes. The speed/incline will be changed depending on the participants' heart rate and perception using the Borg's rating of perceived exertion as needed. Heart rate and exercise energy expenditure during the workout will be monitored. Intensity will be monitored assessing Lactate concentrations at the end of each session. Intervals will be repeated until meeting the targeted exercise energy expenditure (450-500 kcal/session).
Other: Aerobic interval training
Participants in the control group will not participate in the training programs.
The resistance training group
The aerobic interval training group
Changes in Epicardial adipose tissue (EAT)
EAT will be measured using cardiac Magnetic Resonance
Time frame: 2 assessment points: at baseline and week 4
Changes in Vascular Health
Atrial stiffness will be measured using a pulse wave analysis
Time frame: 2 assessment points: at baseline and week 4
Changes in Paracardial adipose tissue (PAT)
PAT will be measured using cardiac Magnetic Resonance
Time frame: 2 assessment points: at baseline and week 4
Changes in Body Composition
Body composition will be measured using dual-energy x-ray absorptiometry
Time frame: 2 assessment points: at baseline and week 4
Changes in Cardiorespiratory Function
Cardiorespiratory Function will be measured on a treadmill with a metabolic cart
Time frame: 2 assessment points: at baseline and week 4
Changes in Muscular Strength
Muscular Strength will be assessed by 1 repetition maximum (1RM) test
Time frame: 2 assessment points: at baseline and week 4
Ran from Oct 2017 to primary completion in Mar 2020, 29 months.
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This study is terminated, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.
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Southern Illinois University Edwardsville