An observational study in Helicobacter Pylori Infection, sponsored by Changhai Hospital. Status unknown. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2017-12-07.
Sponsored by Changhai Hospital · Observational
Retrospectivly follow-up the outpatients for H pylori eradication failures more than 2 times in the digestive department of Changhai hospital from 2015-2017,analyse the eradication rates and adverse effects of the therapy with 2w's compound lactobacillus acidophilus followed by 10d's bismuth, furazolidone, tetracycline contained quadruple scheme.
H pylori infection rate has been up to half of the world population. H pylori infection is associated with various diseases, especially gastric cancer.
With the increasingly resistant to antibiotics,the eradication rate has decreased a lot with traditional triple therapy. Exploring a valid scheem for patients who have failed multiple times is important.
Probiotics can improve gastrointestinal microenvironment, then release the adverse effects during the eradication process.Additionally,there is also a lot evidence that probiotics can inhibit H plori，but still controversially.
There is a low resistant rate about furazolidone and tetracycline. In this study investigators observe the efficacy of the therapy 2w's compound lactobacillus acidophilus followed by 10d's bismuth, furazolidone, tetracycline contained quadruple scheme on patients who have failed more than 2 times. 4 to 6 weeks after the therapy, if Urea Breath Test (UBT) is nedative which means eradicating H plori successfully.
mainland in China
Exclusion Criteria:
urea breath test
if urea breath test is negative,it means H pylori eradicated successfully
Time frame: 4-6 weeks after the quadruple therapy
adverse effects
adverse effects mean the new symptoms during the treatment process,such as nausea,vomiting.
Time frame: 1month
No study locations are listed for this record.
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Changhai Hospital