An interventional study of Low carbohydrate diet and High carbohydrate, high sugar diet in Dyslipidemias, sponsored by Uppsala University. Completed at 1 site in Sweden. Open to participants aged 20 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-11-15.
Sponsored by Uppsala University · Not applicable, Interventional, and Basic science
The overall aim is to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality.
In this isocaloric clinical cross-over trial, the investigators aim to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality. The investigators intend to evaluate if changes in carbohydrate quantity and quality (including sugar) influence circulating even-chain saturated fatty acids or if fatty acid-derived indices of desaturation and de novo lipogenesis are more sensitive biomarkers of carbohydrate intake. By performing untargeted lipidomic analyses, the investigators aim to search for novel lipid biomarkers of carbohydrate quantity and quality. The investigators also want to evaluate the influence of moderate alterations of carbohydrate and sugar intake on lipoproteins, insulin sensitivity, inflammatory proteins.
Exclusion Criteria:
Intervention: consuming diets rich in fat, rich in sugar, and rich in fibers during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.
Other: Low carbohydrate diet · Other: High carbohydrate, high sugar diet · Other: High carbohydrate, low sugar diet
Intervention: consuming diets rich in fat, rich in fiber, and rich sugar during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.
Other: Low carbohydrate diet · Other: High carbohydrate, high sugar diet · Other: High carbohydrate, low sugar diet
Intervention: Consuming diets rich in sugar, rich in fiber, and rich in fat during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.
Other: Low carbohydrate diet · Other: High carbohydrate, high sugar diet · Other: High carbohydrate, low sugar diet
Intervention: Consuming diets rich in sugar, rich in fat, and rich in fiber during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.
Other: Low carbohydrate diet · Other: High carbohydrate, high sugar diet · Other: High carbohydrate, low sugar diet
Intervention: Consuming diets rich in fiber, rich in sugar, and rich in fat during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.
Other: Low carbohydrate diet · Other: High carbohydrate, high sugar diet · Other: High carbohydrate, low sugar diet
Intervention: consuming diets rich in fiber, rich in fat, and rich in fiber during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.
Other: Low carbohydrate diet · Other: High carbohydrate, high sugar diet · Other: High carbohydrate, low sugar diet
Diet low in carbohydrates (38%E), but higher in total and saturated fat.
Diet high in carbohydrates (53%E) and sugars, but low in wholegrain, rye and wheat fibre.
Diet high in carbohydrates (53%E), wholegrain, rye and wheat fibre, but low in sugars.
Palmitic acid in different plasma fractions
Measured by liquid gas chromatography (GC)
Time frame: 14-20 days
Even-chain saturated fatty acids (i.e. 14:0, 18:0) and monounsaturated fatty acids
Measured by liquid GC
Time frame: 14-20 days
Desaturation indices end lipogenic indices
These indices are product-to-precursor fatty acids measured by GC
Time frame: 14-20 days
This study is completed, as verified in Nov 2018. You cannot join it, but the record below documents what was studied.
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Uppsala University