A Phase 3 interventional study of Acetaminophen in Acetaminophen, sponsored by Massachusetts Eye and Ear Infirmary. Status unknown at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-04-10.
Sponsored by Massachusetts Eye and Ear Infirmary · Phase 3, Interventional, and Diagnostic
The primary objective of this study is to investigate the Visual Analog Score (VAS) for pain within the post-operative setting and determine if there is a statistically significant difference between the VAS for PO or IV acetaminophen. It is expected that in doing so the investigators can produce the maximal amount of pain relief after surgery while making conscientious monetary decisions.
Functional Endoscopic Sinus Surgery (FESS) is one of the most common Ear Nose and Throat Surgeries done in the United States annually. This procedure can vary from intense to moderate pain and as such it is difficult to properly gauge and treat postoperative pain in these patients. Commonly used in these cases, opioid drugs are given to provide adequate analgesia, however higher opioid usage is observed to cause increased Post-Anesthesia Care Unit (PACU) stays, respiratory complications and Postoperative Nausea and Vomiting (PONV). Acetaminophen is commonly used as an adjunct in these circumstances because of its opioid sparing properties.
Acetaminophen is a synthetic nonopioid p-aminophenol derivative available over the counter. Its properties include analgesic and antipyretic qualities and it is listed on the world health organization's list of essential medicines. The potential risks include liver damage, skin reactions and drug interactions when used with blood thinners at high doses. Acetaminophen has been extensively researched, in vitro and in vivo studies have found the drug to be safe when used at proper doses. Recently intravenous use of acetaminophen has gained popularity due to ease of use and ability to be given intraoperatively. This form of acetaminophen, although convenient, is around sixty two times the cost of oral acetaminophen. Due to this increased cost it is imperative that the investigators compare the two routes of administration in order to determine if the additional cost is justified.
Exclusion Criteria:
975mg of Acetaminophen given by mouth
Drug: Acetaminophen
1000mg of Acetaminophen given intravenously
Drug: Acetaminophen
Acetaminophen given for pain relief
VAS for pain
First VAS pain score applied
Time frame: 0-1 hour
Opioid Use
Postoperative opioid consumption for pain control
Time frame: 24 hours
Time in PACU
Time required to be admitted and discharged home
Time frame: 3-5 hours
VAS for pain
Second VAS pain score applied
Time frame: 1-2 hours
VAS for pain
Third VAS pain score applied
Time frame: 2-3 hours
VAS for pain
Last VAS pain score applied
Time frame: 24 hours
PONV
Incidence of PONV
Time frame: 24 hours
Plan to share: No
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Massachusetts Eye and Ear Infirmary