An interventional study of peripheral neuromuscular monitor in Postoperative Residual Curarization, sponsored by Onze Lieve Vrouw Hospital. Completed at 1 site in Belgium. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2018-04-10.
Sponsored by Onze Lieve Vrouw Hospital · Not applicable, Interventional, and Diagnostic
The main objective of this study is to describe the incidence of postoperative residual paralysis (mean train-of-four \<90%) when weaning from the ventilator in patients admitted to the Intensive Care Unit (ICU) after elective cardiac surgery. Train-of-four monitoring is a widely used term for the peripheral nerve stimulation used in neuromuscular blockade monitoring. When the patient is ready for weaning from the ventilator, an ICU doctor will perform a measurement of the train-of-four at the thumb with a neuromuscular transmission monitor. Every value below 90% will be considered as residual paralysis and treated appropriately by means of a reversal agent.
Postoperatively, in the ICU, readiness-for-weaning is based on ICU doctor-nurse-driven institutional weaning guidelines: 6 hours after arrival in the ICU, a patient who is normothermic, hemodynamically stable, has normal blood gasses and absence of residual bleeding. The ICU nurse caring for the patient will start weaning the patient from the ventilator, following these departmental guidelines.
98 studies on the registry are indexed under Delayed Emergence from Anesthesia; 17 are open to participants now.
This study's enrollment of 93 is above the median of 83 across 58 interventional studies indexed under Delayed Emergence from Anesthesia.
Browse Delayed Emergence from Anesthesia studies →Onze Lieve Vrouw Hospital is the lead sponsor of 20 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
Residual paralysis can only be measured by neuromuscular transmission monitoring of a peripheral nerve, typically the ulnar nerve innervating the adductor pollicis muscle.
postoperative residual curarisation
mean train-of-four \<90% as measured by neuromuscular blockade monitoring
Time frame: 6 hours after arrival in the ICU
Plan to share: No
Ran from Sep 2017 to primary completion in Jan 2018, 3 months.
Of 20 interventional studies with no phase under Delayed Emergence from Anesthesia, half reached primary completion within 10 months of starting (the median), counting those still running; a quarter within 4 and three quarters within 17. This study's 3 months is below that.
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This study is completed, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.
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Delayed Emergence from Anesthesia →
Onze Lieve Vrouw Hospital