CClinicalTrials.gg
CompletedNCT03287232Updated Apr 9, 2021

Prasterone (DHEA) for the Treatment of Hypoactive Sexual Desire Disorder (HSDD)

A Phase 3 interventional study of Placebo Vaginal Insert and Prasterone 6.5 mg (0.50%) Vaginal Insert in Hypoactive Sexual Desire Disorder, sponsored by EndoCeutics Inc.. Completed at 69 sites in 2 countries. Open to female participants aged 40 Years to 80 Years. Per ClinicalTrials.gov, last updated 2021-04-09.

Sponsored by EndoCeutics Inc. · Phase 3, Interventional, and Treatment

Phase
Phase 3
Study type
Interventional
Enrollment
653
Allocation
Randomized
Ages
40 Years to 80 Years
Sex
Female
01

Study summary

The primary objective is to confirm the efficacy of intravaginal prasterone (DHEA) on Hypoactive Sexual Desire Disorder (HSDD) in postmenopausal women.

02

Conditions studied

  • Hypoactive Sexual Desire Disorder

Keywords

  • Prasterone
  • DHEA
  • Menopause
  • Sexual Disorder
03

Who can participate

Ages eligible
40 Years to 80 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • Postmenopausal women (hysterectomized or not).
  • Women between 40 and 80 years of age.
  • Being in a stable relationship with the opportunity for sexual activity or masturbation at least once a month during the last 6 months or longer (before screening visit) and during the following 8 months.
  • Diagnosis of HSDD confirmed by a qualified clinician.
  • Willing to participate in the study and sign an informed consent.

Exclusion criteria

Exclusion Criteria (main criteria):

  • Chronic or acute life stress or major life change that could have interfered and continues to interfere significantly with sexual activity.
  • Taking drugs which could be responsible for HSDD.
  • Severe medical condition which can explain the loss of sexual desire.
  • The administration of any investigational drug within 30 days of screening visit.
  • Clinically significant abnormal serum biochemistry, urinalysis or hematology.
04

Study design

Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment
653 participants (actual)

Study arms

  • Placebo comparator
    Placebo

    Drug: Placebo Vaginal Insert

  • Experimental
    Prasterone

    Drug: Prasterone 6.5 mg (0.50%) Vaginal Insert

Interventions

  • DrugPlacebo Vaginal Insert

    Daily administration of a placebo vaginal insert.

  • DrugPrasterone 6.5 mg (0.50%) Vaginal Insert

    Daily administration of a 6.5 mg (0.50%) prasterone vaginal insert.

05

What researchers measure

Primary outcomes

  1. Sexual desire

    Change from Baseline in sexual desire evaluated by the FSFI desire domain (Questions 1 \& 2).

    Time frame: 28 weeks

  2. Distress from low sexual desire

    Change from Baseline in distress from low sexual desire evaluated by question 13 of FSDS-DAO.

    Time frame: 28 weeks

Secondary outcomes

  1. Satisfying sexual events (SSEs)

    Change from Baseline in the number of SSEs from a daily log of sexual activity.

    Time frame: 28 weeks

06

Study locations

69 sites
  • Endoceutics site # 106
    Huntsville, Alabama 35801, United States
  • Endoceutics site # 104
    Mobile, Alabama 36608, United States
  • Endoceutics site # 117
    Tucson, Arizona 85712, United States
  • Endoceutics site # 108
    Berkeley, California 84704, United States
  • Endoceutics site # 121
    Los Alamitos, California 90720, United States
  • Endoceutics site #128
    Los Angeles, California 90024, United States
  • Endoceutics site # 30
    San Diego, California 92108, United States
  • Endoceutics site # 17
    San Diego, California 92120, United States
  • Endoceutics site # 36
    Denver, Colorado 80209, United States
  • Endoceutics site # 52
    Denver, Colorado 80220, United States
  • Endoceutics site # 125
    New London, Connecticut 06320, United States
  • Endoceutics site # 7
    Washington, District of Columbia 20036, United States
  • Endoceutics site # 95
    Bradenton, Florida 34201, United States
  • Endoceutics site # 120
    Coral Gables, Florida 33134, United States
  • Endoceutics site # 99
    Fort Myers, Florida 33912, United States
  • Endoceutics site # 26
    Jacksonville, Florida 32207, United States
  • Endoceutics site # 60
    Lake Worth, Florida 33461, United States
  • Endoceutics site #118
    Miami Lakes, Florida 33014, United States
  • Endoceutics site # 54
    North Miami, Florida 33161, United States
  • Endoceutics site # 92
    Oviedo, Florida 32765, United States
  • Endoceutics site # 114
    Saint Petersburg, Florida 33709, United States
  • Endoceutics site # 105
    Sanford, Florida 32771, United States
  • Endoceutics site # 89
    West Palm Beach, Florida 33401, United States
  • Endoceutics site # 80
    West Palm Beach, Florida 33409, United States
  • Endoceutics site # 90
    West Palm Beach, Florida 33409, United States
  • Endoceutics site # 107
    Decatur, Georgia 30030, United States
  • Endoceutics site # 119
    Roswell, Georgia 30075, United States
  • Endoceutics site # 23
    Sandy Springs, Georgia 30328, United States
  • Endoceutics site # 91
    Savannah, Georgia 31406, United States
  • Endoceutics site # 111
    Wichita, Kansas 67207, United States
  • Endoceutics site # 55
    Wichita, Kansas 67226, United States
  • Endoceutics site # 88
    Lexington, Kentucky 40509, United States
  • Endoceutics site # 86
    Louisville, Kentucky 40291, United States
  • Endoceutics site # 103
    Boston, Massachusetts 02131, United States
  • Endoceutics site # 22
    Kalamazoo, Michigan 49009, United States
  • Endoceutics site # 123
    Portsmouth, New Hampshire 03801, United States
  • Endoceutics site # 101
    Berlin, New Jersey 08009, United States
  • Endoceutics site # 50
    Neptune, New Jersey 07753, United States
  • Endoceutics site # 44
    New Brunswick, New Jersey 08901, United States
  • Endoceutics site # 81
    Plainsboro, New Jersey 08536, United States
  • Endoceutics site # 20
    New York, New York 10016, United States
  • Endoceutics site # 110
    Poughkeepsie, New York 12601, United States
  • Endoceutics site # 97
    Rochester, New York 14609, United States
  • Endoceutics site # 58
    Raleigh, North Carolina 27612, United States
  • Endoceutics site # 115
    Fargo, North Dakota 58103, United States
  • Endoceutics site # 116
    Canton, Ohio 44718, United States
  • Endoceutics site # 100
    Cleveland, Ohio 44106, United States
  • Endoceutics site # 5
    Cleveland, Ohio 44122, United States
  • Endoceutics site # 93
    Columbus, Ohio 43213, United States
  • Endoceutics site # 75
    Philadelphia, Pennsylvania 19114, United States
  • Endoceutics site # 127
    Bluffton, South Carolina 29910, United States
  • Endoceutics site # 126
    Mount Pleasant, South Carolina 29464, United States
  • Endoceutics site # 112
    Myrtle Beach, South Carolina 29572, United States
  • Endoceutics site # 94
    Chattanooga, Tennessee 37404, United States
  • Endoceutics site # 64
    Jackson, Tennessee 38305, United States
  • Endoceutics site #124
    Knoxville, Tennessee 37920, United States
  • Endoceutics site #122
    Nashville, Tennessee 37203, United States
  • Endoceutics site # 82
    Houston, Texas 77030, United States
  • Endoceutics site # 102
    San Antonio, Texas 78229, United States
  • Endoceutics site # 96
    Charlottesville, Virginia 22942, United States
  • Endoceutics site # 3
    Norfolk, Virginia 23507, United States
  • Endoceutics site # 98
    Norfolk, Virginia 23507, United States
  • Endoceutics site # 76
    Seattle, Washington 98105, United States
  • Endoceutics site # 68
    Sarnia, Ontario N7T 4X3, Canada
  • Endoceutics site # 18
    Lévis, Quebec G6W 0M5, Canada
  • Endoceutics site # 02
    Québec, Quebec G1S 2L6, Canada
  • Endoceutics site # 77
    Québec, Quebec G1W 4R4, Canada
  • Endoceutics site # 78
    Québec, Quebec G3K 2P8, Canada
  • Endoceutics site # 11
    Sherbrooke, Quebec J1L 0H8, Canada
07

References and documents

Publications

  • Labrie F, Archer D, Bouchard C, Fortier M, Cusan L, Gomez JL, Girard G, Baron M, Ayotte N, Moreau M, Dube R, Cote I, Labrie C, Lavoie L, Berger L, Gilbert L, Martel C, Balser J. Effect of intravaginal dehydroepiandrosterone (Prasterone) on libido and sexual dysfunction in postmenopausal women. Menopause. 2009 Sep-Oct;16(5):923-31. doi: 10.1097/gme.0b013e31819e85c6. PubMed 19424093 ↗
  • Labrie F, Derogatis L, Archer DF, Koltun W, Vachon A, Young D, Frenette L, Portman D, Montesino M, Cote I, Parent J, Lavoie L, Beauregard A, Martel C, Vaillancourt M, Balser J, Moyneur E; Members of the VVA Prasterone Research Group. Effect of Intravaginal Prasterone on Sexual Dysfunction in Postmenopausal Women with Vulvovaginal Atrophy. J Sex Med. 2015 Dec;12(12):2401-12. doi: 10.1111/jsm.13045. Epub 2015 Nov 23. PubMed 26597311 ↗
  • Bouchard C, Labrie F, Derogatis L, Girard G, Ayotte N, Gallagher J, Cusan L, Archer DF, Portman D, Lavoie L, Beauregard A, Cote I, Martel C, Vaillancourt M, Balser J, Moyneur E; VVA Prasterone Group. Effect of intravaginal dehydroepiandrosterone (DHEA) on the female sexual function in postmenopausal women: ERC-230 open-label study. Horm Mol Biol Clin Investig. 2016 Mar;25(3):181-90. doi: 10.1515/hmbci-2015-0044. PubMed 26725467 ↗

Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT03287232
Lead sponsor
EndoCeutics Inc.
Responsible party
Sponsor
First posted
Sep 19, 2017
Start date
Oct 16, 2017
Primary completion
Mar 8, 2019
Completion
Jul 22, 2019
Last update
Apr 9, 2021

Study contacts

Claude Labrie, M.D., Ph.D.
study chair · EndoCeutics Inc.
Leonard R. Derogatis, Ph.D.
principal investigator · Maryland Center for Sexual Health

Oversight

Data monitoring committee
No
FDA-regulated drug
Yes
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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