An interventional study of Broccoli consumption in Healthy Volunteers, sponsored by USDA Beltsville Human Nutrition Research Center. Completed at 1 site in United States. Open to participants aged 21 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-11-21.
Sponsored by USDA Beltsville Human Nutrition Research Center · Not applicable, Interventional, and Other
The objectives of the study are 1) to characterize plasma and urinary metabolites that originate from glucobrassicin, 1-methoxyglucobrassicin, 4-methoxyglucobrassicin, and 4-hydroxyglucobrassicin, which are the major indole glucosinolates found in broccoli, and 2) to identify novel plasma and urinary metabolites following broccoli consumption that may have roles in reducing the risk of cancer.
Consumption of Brassica vegetables is inversely associated with incidence of several cancers, including cancer of the lung, stomach, liver, colon, rectum, breast, endometrium, and ovaries. Brassicas are a good source of many nutrients, but the unique characteristic of Brassicas is their rich content of glucosinolates. Breakdown products of indole glucosinolates in Brassica vegetables show promise for reducing the risk of cancer, but have received comparatively less research attention than those of aliphatic glucosinolates. The aim of this study is to investigate plasma and urinary metabolites of indole glucosinolates from broccoli and to identify novel metabolites that may have roles in reducing cancer risk.
Exclusion Criteria:
Subjects will consume a dose of broccoli on day 11
Other: Broccoli consumption
All subjects will eat broccoli on day 11
The change in glucosinolate metabolites will be measured in blood plasma and urine.
To track the changes of indole glucosinolate metabolites, glucosinolate metabolites will be measured in both blood plasma and urine.
Time frame: On Day 11
Plan to share: No
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USDA Beltsville Human Nutrition Research Center