An interventional study of Aerobic-based exercise program in Physical Exercise, Cerebrovascular Function and Cerebral Blood Flow, sponsored by Maastricht University Medical Center. Completed at 1 site in Netherlands. Open to male participants aged 60 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-01-16.
Sponsored by Maastricht University Medical Center · Not applicable, Interventional, and Prevention
Cognitive performance is negatively related to an impaired glucose metabolism, possibly due to impairments in brain vascular function. Supported by the statement from the American Heart and Stroke Association that physical exercise is one of the most effective strategies to protect against cognitive decline, we now hypothesize that exercise-induced changes in glucose metabolism cause beneficial effects on brain vascular function thereby improving cognitive performance. The primary objective of this intervention study is thus to evaluate in sedentary elderly men the effect of a 8-week aerobic-based exercise program on cerebral blood flow, as quantified by the non-invasive gold standard magnetic resonance imaging (MRI) perfusion method Arterial Spin Labeling (ASL). Cerebral blood flow is a robust and sensitive physiological marker of brain vascular function. Secondary objectives are to examine effects on glucose metabolism using the oral glucose tolerance test and cognitive performance as assessed with a neurophysiological test battery.
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This study's enrollment of 19 is below the median of 60 across 2,309 interventional studies indexed under Motor Activity.
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Exclusion Criteria:
Other: Aerobic-based exercise program
Maintenance of habitual physical activity levels
Aerobic-based exercise will be carried out on a cycling ergometer three times a week for 30 minutes at 70% of the maximal workload. Every two weeks, the maximal workload will be reassessed, and training loads will be readjusted accordingly. Fully supervised training sessions will be performed with three-to-four study participants at a time. Subjects should maintain their body weight during the intervention period.
Brain vascular function
Cerebral blood flow as quantified non-invasively by the MRI perfusion method Arterial Spin Labeling (ASL)
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Glucose metabolism
Oral Glucose Tolerance Test (OGTT)
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Cognitive performance
Cambridge Neuropsychological Test Automated Battery (CANTAB)
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Other physiological parameters: Peripheral vascular function
Flow-mediated vasodilation (FMD), carotid artery reactivity, pulse wave analysis (PWA) and velocity (PWV), and retinal images
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Other physiological parameters: Blood pressure
Office and 24-hour ambulatory blood pressure
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Other physiological parameters: Continuous blood glucose
36-hour glycaemic response
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Other physiological parameters: Advanced glycation endproducts
Serum protein-bound advanced glycation endproducts (AGEs)
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Other physiological parameters: Conventional metabolic risk markers
Lipids and lipoproteins, glucose and insulin, and markers for low-grade systemic inflammation and microvascular function
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Other perceivable benefits: Quality of Life
The Quality of life (QoL) will be assessed using a 32-item questionnaire
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Other perceivable benefits: Sleep characteristics
Sleep characteristics will be assessed using the 10-item Pittsburgh Sleep Quality Index
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Other perceivable benefits: Mood
Mood will be tested using the Affect Grid
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Other perceivable benefits: Physical fitness (1)
Incremental exhaustive exercise test (VO2 max)
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Other perceivable benefits: Physical fitness (2)
Timed up-and-go test (TUGT)
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Other perceivable benefits: Physical fitness (3)
The 6-minute walk test (6 MWT)
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
Other perceivable benefits: Physical fitness (4)
Handgrip and muscle strength tests
Time frame: Difference between outcomes at the end of an 8-week aerobic-based exercise and control program
This study is completed, as verified in Jan 2019. You cannot join it, but the record below documents what was studied.
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