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Status unknownNCT03259672Updated Aug 24, 2017

Influence of Sevoflurane and Desflurane on Postoperative Sore Throat

An interventional study of Sevoflurane and Desflurane in Hip Arthroplasty, sponsored by Keimyung University Dongsan Medical Center. Status unknown. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2017-08-24.

Sponsored by Keimyung University Dongsan Medical Center · Not applicable, Interventional, and Prevention

The sponsor has not verified this record recently (last verified Aug 2017), so the status shown — last known as Not yet recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
100
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

This investigation is planned to compare the incidence and severity of postoperative sore throat according to the use of sevoflurane or desflurane.

02

Conditions studied

  • Hip Arthroplasty

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Keywords

  • intubation
  • pharyngitis
  • remifentanil
03

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • ASA I-III
  • Patients scheduled for general anesthesia with endotracheal intubation

Exclusion criteria

Exclusion Criteria:

  • Difficult airway
  • Friable teeth
  • Rapid sequence induction
  • Recent sore throat
  • Recent upper respiratory infection
  • Asthma
  • Chronic obstructive pulmonary disease
  • Chronic cough
  • Arrhythmia
  • Coronary disease
  • Heart failure
  • Pregnancy
  • Allergy to sevoflurane
  • Allergy to desflurane
  • Fever after halogenated anesthetics
  • Jaundice after halogenated anesthetics
  • Malignant hyperthremia
  • Allergy to remifentanil
  • Friable teeth
  • History of head and neck surgery
  • Multiple intubation attempts
  • Regional anesthetic agents
  • Gastric tube
  • Dexamethasone
  • Severe hypovolemia
04

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
100 participants (estimated)

Study arms

  • Active comparator
    Sevoflurane

    Drug: Sevoflurane

  • Experimental
    Desflurane

    Drug: Desflurane

Interventions

  • DrugSevoflurane

    Sevoflurane was used as a maintenance anesthetic agent.

  • DrugDesflurane

    Desflurane was used as a maintenance anesthetic agent.

05

What researchers measure

Primary outcomes

  1. Number of participants with postoperative sore throat

    Time frame: At 24 hr

Secondary outcomes

  1. Number of participants with postoperative sore throat

    Time frame: At 0, 2, 4 and 24 hr

  2. Number of participants with postoperative hoarseness

    Time frame: At 0, 2, 4 and 24 hr

  3. Number of participants with postoperative cough

    Time frame: At 0, 2, 4 and 24 hr

  4. Number of participants with postoperative nausea

    Time frame: At 0, 2, 4 and 24 hr

  5. Number of participants with postoperative vomiting

    Time frame: At 0, 2, 4 and 24 hr

  6. Number of participants with additional pain medication

    Time frame: At 0, 2, 4 and 24 hr

  7. Visual analogue scale of postoperative pain

    Time frame: At 0, 2, 4 and 24 hr

  8. Number of participants with shivering

    Time frame: At 0, 2, 4 and 24 hr

  9. Requirements of analgesics

    Time frame: At 0, 2, 4 and 24 hr

06

Study locations

No study locations are listed for this record.

07

Registry details

Key details

Study ID
NCT03259672
Lead sponsor
Keimyung University Dongsan Medical Center
Responsible party
Hyun-Chang Kim (Assistant professor, Keimyung University Dongsan Medical Center) — Principal investigator
First posted
Aug 24, 2017
Start date
Oct 1, 2017 (estimated)
Primary completion
Oct 1, 2018 (estimated)
Completion
Nov 1, 2018 (estimated)
Last update
Aug 24, 2017

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is status unknown, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.

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