An interventional study of High flow humidified oxygen therapy in Bronchiolitis, Viral, sponsored by Chris Hani Baragwanath Academic Hospital. Terminated at 1 site in South Africa. Open to participants aged 1 Month to 2 Years. Per ClinicalTrials.gov, last updated 2019-07-24.
Sponsored by Chris Hani Baragwanath Academic Hospital · Not applicable, Interventional, and Treatment
A randomized control trial of 130 infants admitted to the paediatric high care admission ward will be enrolled, and randomized to either "high flow humidified oxygen" or "standard therapy".
A randomized control trial of 130 infants admitted to the paediatric high care admission ward will be enrolled. Infants between 1 month and 2 years of age who fulfill criteria for enrollment shall be considered eligible. Informed consent from parents or legal guardians shall be obtained. Infants shall be randomized to either "standard therapy" or "high flow humidified oxygen". Measurements of heart rate, respiratory rate, work of breathing (Tal score and WCAS), oxygen saturation and oxygen requirements shall be recorded.
Exclusion Criteria:
standard treatment of viral bronchiolitis with low flow oxygen.
treatment of viral bronchiolitis with high flow humidified oxygen therapy.
Device: High flow humidified oxygen therapy
application of high flow humidified oxygen therapy at 2l/kg/min
Effect of high flow humidified oxygen therapy on work of breathing
Respiratory rate (n/min)
Time frame: during first 5 days post enrollment
Effect of high flow humidified oxygen therapy on work of breathing
Use of accessory muscles of respiration (present /not)
Time frame: first 5 days post enrollment
Effect of high flow humidified oxygen therapy on blood oxygen saturations
Saturation of oxygen (% saturation) as measured by pulse oximeter
Time frame: first 5 days post enrollment
Effect of high flow humidified oxygen therapy on heart rate
Pulse (n/min) measured by ECG monitor
Time frame: first 5 days post enrollment
Proportion of patients requiring intubation and ventilation
number of patients (N) getting intubated
Time frame: from time of enrollment to end of hospital stay (up to 6 months)
Length of hospital stay
days (N) spent in hospital
Time frame: from time of enrollment to end of hospital stay (up to 6 months)
Plan to share: No — No plan to share data wit other researchers
No publications or documents are linked to this record.
This study is terminated, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.
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Chris Hani Baragwanath Academic Hospital