An observational study in COPD Exacerbation, Physical Activity and Retinal Vascular, sponsored by Hasselt University. Status unknown at 1 site in Belgium. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2017-09-08.
Sponsored by Hasselt University · Observational
Among 13 studies in Motor Activity by Hasselt University — 4 open to participants now, 6 under way, none of them phase 3. Motor Activity · Hasselt University.
Among the 13 studies in Motor Activity by Hasselt University, this one is the only one that started in 2017, is one of 5 observational ones, and was the 2nd registered.
9,798 studies on the registry are indexed under Motor Activity; 1,910 are open to participants now.
Browse Motor Activity studies →4 of the 13 studies in Motor Activity by Hasselt University are open now, in 1 country. Recruiting first, the newest first:
Hasselt University · Sites in Belgium
Hasselt University · Sites in Belgium
Hasselt University · Sites in Belgium
Hasselt University · Sites in Belgium
By country, each count listing its studies:
Of the 1,201 Motor Activity studies recruiting now, 517 (43%) set no upper age limit and 535 (45%) stop at 75 or younger; 180 take children under 18; 420 take healthy volunteers.
This study: 40 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
13 studies; the count open now beside each. This study's row is marked.
First in 2015; this study’s year is marked. 1 started in 2017.
This study's planned enrollment of 100 is close to the median of 98 across 1,235 observational studies indexed under Motor Activity.
Median enrollment 27 across the 8 interventional studies, 100 across the 5 observational. Of the 4 that completed or were terminated, 0 (0%) have results posted.
This tab as a report to print or save as PDF → With an account.
Hasselt University is the lead sponsor of 204 studies on the registry; 31 are open to participants now.
None of the studies under way reaches primary completion within a year.
Among the 13 studies in Motor Activity by Hasselt University, from their registry updates:
Nothing recorded among them since 2026-09-25.
This tab as a report to print or save as PDF → With an account.
This study investigates the influence of acute exacerbation of chronic obstructive pulmonary disease (COPD) on retinal microcirculation, on functional status and also investigates the prognostic value of retinal vessel caliber assessment in terms of hospitalization and mortality during 2 years of follow-up.
Recent findings suggest that patients with chronic obstructive pulmonary disease (COPD) are at increased risk for myocardial infarction and stroke during periods of acute exacerbation. These findings might be related to acute endothelial changes associated to increased systemic inflammation. Changes in the microcirculation can be explored noninvasively by studying retinal blood vessels that are visualized in fundus images. The retinal blood vessels have anatomical and physiological features that are comparable with the coronary circulation.
Patients with COPD experience quadriceps muscle weakness, which worsens during hospitalization by \~1% per day. This is the result of physical inactivity, in combination with increased oxidative stress and systemic inflammation. Physical inactivity is induced by the hospital environment, but is also related to symptoms of dyspnea caused by increased work of breathing and oxygen desaturation.
Muscle weakness and physical inactivity are associated to poor functional status and recurrent hospital admissions, independent of pulmonary impairment, which makes those patients with frequent exacerbations prone to enter a vicious cycle.
Simple functional screening tests during hospital stay might enable us to quantify the impact of a hospitalization on functional status and to identify patients at risk for repeated exacerbations.
Stable and exacerbated COPD patients
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Stable COPD patients at pulmonology consultation in Ziekenhuis Oost-Limburg (ZOL) Genk
Patients admitted to the respiratory ward of ZOL Genk with a diagnosis of acute exacerbation, based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria.
Changes in Retinal microcirculation
Fundus of the right eye will be photographed using a retinal camera. The vessel diameters had geometric patterns will be measure.
Time frame: Stable: Outpatient clinic/ COPD exacerbated: Day 2-3 in hospital; Day 5-7 in hospital; 4 weeks after discharge
Changes in Functional status tests
Short physical performance battery (SPPB), which consists of a four meter gait test, a five-repetition sit-to-stand test and a balance test will be done. All the testes ranged from 0 to 4 and the sum of the three components comprised the final SPPB score, with a possible range from 0 to 12.
Time frame: Stable: Outpatient clinic/ COPD exacerbated: Day 2-3 in hospital; Day 5-7 in hospital; 4 weeks after discharge
Functional exercise tolerance
Six minute walk test will be done
Time frame: Stable: Outpatient clinic/ COPD exacerbated: Day 2-3 in hospital; Day 5-7 in hospital; 4 weeks after discharge
Muscle Function
Handgrip and Isometric-eccentric quadriceps strength test will be done
Time frame: Stable: Outpatient clinic/ COPD exacerbated: Day 2-3 in hospital; Day 5-7 in hospital; 4 weeks after discharge
Changes in Daily physical activity
Activity level will be assess by an accelerometer, the patient will be worn for 7 days.
Time frame: Stable: Outpatient clinic/ COPD exacerbated: Day 2-3 in hospital; Day 5-7 in hospital; 4 weeks after discharge
Impact of the disease
The COPD assessment test will be applied
Time frame: Stable: Outpatient clinic/ COPD exacerbated: Day 2-3 in hospital; Day 5-7 in hospital; 4 weeks after discharge
Impact of the dyspnea
The modified medical research council scale will be applied
Time frame: Stable: Outpatient clinic/ COPD exacerbated: Day 2-3 in hospital; Day 5-7 in hospital; 4 weeks after discharge
Impact of the depression
The patient health questionnaire will be applied
Time frame: Stable: Outpatient clinic/ COPD exacerbated: Day 2-3 in hospital; Day 5-7 in hospital; 4 weeks after discharge
Impact of the fatigue
The checklist individual strength- fatigue sub-scale will be applied
Time frame: Stable: Outpatient clinic/ COPD exacerbated: Day 2-3 in hospital; Day 5-7 in hospital; 4 weeks after discharge
Body composition
Bio-electrical impedance analysis will be used to estimate fat-free body mass based on the assessment of total body water. Body mass index and waist circumference will provide general information about body composition.
Time frame: Stable: Outpatient clinic/ COPD exacerbated: Day 2-3 in hospital; Day 5-7 in hospital; 4 weeks after discharge
Cardiovascular parameters
Resting ankle and brachial blood pressure will be measured and the ankle brachial pressure index will be calculated by the ratio of ankle to ipsilateral brachial systolic blood pressure
Time frame: Stable: Outpatient clinic/ COPD exacerbated: Day 2-3 in hospital; Day 5-7 in hospital; 4 weeks after discharge
Continuous assessment of oxygen saturation
A portable pulse oximeter will be worn to asses transcutaneous oxygen saturation for 24 hours in patients with an exacerbation.
Time frame: COPD exacerbated: Day 5-7 in hospital; 4 weeks after discharge
Continuous assessment of heart rate
A portable pulse oximeter will be worn to asses heart rate for 24 hours in patients with an exacerbation.
Time frame: COPD exacerbated: Day 5-7 in hospital; 4 weeks after discharge
Plan to share: No
No publications or documents are linked to this record.
Started Sep 2017 (actual). Primary completion is estimated for Jul 2018, 9 months after the start.
Of 490 non-industry observational studies under Motor Activity, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 48. This study's planned 9 months is below that.
Counting every sponsor, half of 500 studies reached it within 22 months; a quarter within 8 and three quarters within 48.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Sep 2017. You cannot join it, but the record below documents what was studied.
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